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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
Bone Res
February 2024
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for bone-anabolic processes, there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in cartilage. Here we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis (OA) development.
View Article and Find Full Text PDFBizarre parosteal osteochondromatous proliferation: an educational review.
Insights Imaging
June 2023
IRCCS Istituto Ortopedico Galeazzi, via Cristina Belgioioso 173, 20157, Milan, Italy.
Bizarre parosteal osteochondromatous proliferation (BPOP) is a surface-based bone lesion belonging to the group of benign chondrogenic tumors. The aim of this review is to familiarize the readers with imaging features and differential diagnosis of BPOP, also addressing pathological presentation and treatment options. The peak of incidence of BPOP is in the third and fourth decades of life, although it can occur at any age.
View Article and Find Full Text PDFA Unique Case of Recurrent Osteochondroma Enclosing Brachial Artery in a 13-Year-Old Female.
J Orthop Case Rep
March 2022
Department of Orthopaedics, Padmashree Dr. D.Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Introduction: Osteochondromas (OCEs) are benign chondrogenic lesions arising on the external surface of the bone with aberrant cartilage (exostosis) from the perichondral ring that may contain a marrow cavity also. In few cases, depending on the anatomical site affected, different degrees of edema, redness, paresthesia, or paresis can take place due to simple contact or friction. Furthermore, depending on their closeness to neurovascular structures, the procedure of excision becomes crucial to avoid recurrence.
View Article and Find Full Text PDFForearm Hereditary Multiple Exostosis: A Retrospective Case Series Study.
Cureus
June 2022
Departments of Surgery and Orthopedic Surgery, King Faisal Specialist Hospital & Research Centre, Riyadh, SAU.
Background Hereditary multiple exostosis (HME) is a significantly rare genetic condition with benign chondrogenic lesions affecting long bones. Forearm involvement is relatively common, with varied treatment modalities reported. Here we describe our experience with HME.
View Article and Find Full Text PDFANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease.
Osteoarthritis Cartilage
May 2022
Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium; Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium. Electronic address:
Objectives: To investigate how ANP32A, previously linked to the antioxidant response, regulates Wnt signaling as unraveled by transcriptome analysis of Anp32a-deficient mouse articular cartilage, and its implications for osteoarthritis (OA) and diseases beyond the joint.
Methods: Anp32a knockdown chondrogenic ATDC5 cells were cultured in micromasses. Wnt target genes, differentiation markers and matrix deposition were quantified.
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