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Advances in Heavy Metal Sensing: Utilizing Immobilized Chromogenic Reagents, Nanomaterials Perovskite and Nanonzymes.
Crit Rev Anal Chem
January 2025
Department of Chemistry, University of Delhi, New Delhi, India.
Heavy metal pollution is a major environmental and health problem due to the toxicity and persistence of metals such as lead, mercury, cadmium, and arsenic in water, soil, and air. Advances in sensor technology have significantly improved the detection and quantification of heavy metals, providing real-time monitoring and mitigation tools. This review explores recent developments in heavy metal detection, focusing on innovative uses of immobilized chromogenic reagents, nanomaterials, perovskites, and nanozymes.
View Article and Find Full Text PDFControlling mission hazards through integrated abort and spare support optimization.
Risk Anal
January 2025
School of Management, Beijing Institute of Technology, Beijing, China.
This study explores the risk management challenges associated with safety-critical systems required to execute specific missions. The working component experiences degradation governed by a continuous-time discrete-state Markov chain, whose failure leads to an immediate system breakdown and safety losses. To enhance system survivability, a limited number of identical spares are available for online replacement throughout the mission.
View Article and Find Full Text PDFInhibition of PGAM5 hyperactivation reduces neuronal apoptosis in PC12 cells and experimental vascular dementia rats.
Arch Gerontol Geriatr
December 2024
Neurology Ward 1, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Qingxiu District, Nanning, 530001, China. Electronic address:
Purpose: The incidence of vascular dementia (VaD), as one of the main types of dementia in old age, has been increasing year by year, and exploring its pathogenesis and seeking practical and effective treatment methods are undoubtedly the key to solving this problem. Phosphoglycerate translocase 5 (PGAM5), as a crossroads of multiple signaling pathways, can lead to mitochondrial fission, which in turn triggers the onset and development of necroptosis, and thus PGAM5 may be a novel target for the prevention and treatment of vascular dementia.
Methods: Animal model of vascular dementia was established by Two-vessel occlusion (2-VO) method, and cellular model of vascular dementia was established by oxygen glucose deprivation (OGD) method.
Childhood irritability-aggression profiles and parent-to-child violence: Evidence of interactive effect in predicting youth violence.
Child Abuse Negl
January 2025
Mental Health Education Center, Southeast University, 2 Southeast University Road, Nanjing, Jiangsu 211189, China. Electronic address:
Objective: Early irritability, aggression, and parent-to-child violence (PCV) each are presumed to predict later violent behavior. Few studies, however, have examined these factors simultaneously. This study investigated how irritability and aggression jointly manifested during childhood and whether such manifestations, PCV, and their interactions were associated with late-adolescent violence.
View Article and Find Full Text PDFRecent Prospectives of Cellular Signaling Role for Mammary Gland Carcinogenesis.
Anticancer Agents Med Chem
January 2025
Department of Pharmaceutical Sciences, Lucknow University, Lucknow, UP, India.
In women globally, breast cancer ranks as the second most frequent cause of cancer-related deaths, making up about 25% of female cancer cases, which is pretty standard in affluent countries. Breast cancer is divided into subtypes based on aggressive, genetic and stage. The precise cause of the problem is still unknown.
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