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Hypercalcemia Following Adrenalectomy for Cushing Syndrome in a Patient with Post-Surgical Hypoparathyroidism.
Diseases
January 2025
Unit of Endocrinology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Fondazione Policlinico "A. Gemelli" IRCCS, Largo Gemelli 8, 00168 Rome, Italy.
Hypercalcemia is a frequently encountered laboratory finding in endocrinology, warranting accurate clinical and laboratory evaluation to identify its cause. While primary hyperparathyroidism and malignancies represent the most common causes, many other etiologies have been described, including some reports of hypercalcemia secondary to adrenal insufficiency. On the contrary, hypoparathyroidism is a relatively common cause of hypocalcemia, often arising as a complication of thyroid surgery.
View Article and Find Full Text PDFChapter 4: Differential diagnosis of primary hyperparathyroidism.
Ann Endocrinol (Paris)
January 2025
Service d'endocrinologie, diabétologie, métabolisme, nutrition, hôpital Huriez, CHU de Lille, 1, rue Polonovski, 59037 Lille cedex, France; Inserm U1190, institut génomique européen pour le diabète, université de Lille, 59000 Lille, France. Electronic address:
The differential diagnosis of primary hyperparathyroidism can be considered clinically, biologically and radiologically. Clinically, primary hyperparathyroidism should be suspected in case of diffuse pain, renal lithiasis, osteoporosis, repeated fracture, cognitive or psychiatric disorder, or disturbance of consciousness. Nevertheless, the differential diagnosis of primary hyperparathyroidism is mainly biological, particularly in atypical forms, which must be differentiated from hypercalcemia with hypocalciuria or non-elevated PTH on the one hand, and from normo-calcemia with elevated PTH, hypophosphatemia or hypercalciuria on the other.
View Article and Find Full Text PDFIdiopathic infantile hypercalcemia with a variant triggered by vitamin D supplementation in fortified milk: A case report.
Clin Pediatr Endocrinol
January 2025
Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Idiopathic infantile hypercalcemia (IIH) is characterized by hypercalcemia, nephrocalcinosis, vomiting, dehydration, and failure to thrive. It is caused by the presence of biallelic loss-of-function variants in the locus. Although hypercalcemia has been linked to the consumption of vitamin D-fortified milk, no reports have documented its role in triggering IIH in patients with variants.
View Article and Find Full Text PDFA Rare Case of Isolated Extrapulmonary Sarcoidosis With Renal Involvement Sans Pulmonary Findings: Diagnostic Challenges and Clinical Insights.
Cureus
August 2024
Nephrology, Wellstar Spalding Medical Center, Griffin, USA.
Article Synopsis
- Sarcoidosis is an unknown multi-system disease characterized by granulomas, primarily seen in the lungs but can also cause lymph node issues and rarely affects the kidneys.
- A case study of a 59-year-old man reveals that despite normal chest imaging, he was diagnosed with sarcoidosis due to symptoms like renal failure and the presence of noncaseating granulomas in a skin biopsy.
- The report emphasizes that sarcoidosis can present without lung symptoms, suggesting that doctors should consider it when diagnosing unexplained high calcium levels, even in the absence of typical lung or skin signs.
A retrospective case series on bisphosphonate related osteonecrosis of the jaw in 20 cats.
Front Vet Sci
August 2024
Veterinary Dental Services LLC., Boxborough, MA, United States.
Introduction: This retrospective study highlights the salient aspects of a series of feline patients affected with bisphosphonate related osteonecrosis of the jaw. Though more commonly published in human literature, this presentation is rare in cats. The authors hope that this study will assist in making this a more globally known entity with subsequent improved prognosis.
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