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Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation.
Intensive Care Med Exp
November 2024
Critical Care Research Group, The Prince Charles Hospital, Level 3, Clinical Sciences Building, Chermside Qld 4032, Brisbane, QLD, Australia.
Article Synopsis
- - Open-lung ventilation during cardiopulmonary bypass (CPB) may help reduce postoperative lung damage in heart transplant patients, based on a study using sheep models to compare ventilatory strategies during surgery.
- - The study found that the group receiving open-lung ventilation had significantly less lung damage and inflammatory cell infiltration compared to the group that received no ventilation (measured by histological scores).
- - Despite showing benefits in lung protection, no significant differences were observed in overall hemodynamic stability between the two groups, indicating the need for more research to confirm these findings in clinical settings.
A Natural Carbon Encapsulated in Gellan-Based Hydrogel Particles Designed for Environmental Challenges.
Gels
November 2024
Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 73, Prof. Dr. Docent D. Mangeron Street, 700050 Iasi, Romania.
This article reports the obtention of a new gellan-based hydrogel linked with Fe and loaded with a natural micro/nanostructured carbon designed as a contaminant's removal from wastewater. Hydrogels are known for their water-retaining properties, high binding capacity, and eco-friendly features. The new material is expected to behave as one cost-effective and efficient sorbent, including natural carbon structures with various functional groups.
View Article and Find Full Text PDFAn Artificial Intelligence Algorithm for Detection of Severe Aortic Stenosis: A Clinical Cohort Study.
JACC Adv
September 2024
Institute of Health Research, The University of Notre Dame Australia, Fremantle, Western Australia, Australia.
Background: Identifying individuals with severe aortic stenosis (AS) at high risk of mortality remains challenging using current clinical imaging methods.
Objectives: The purpose of this study was to evaluate an artificial intelligence decision support algorithm (AI-DSA) to augment the detection of severe AS within a well-resourced health care setting.
Methods: Agnostic to clinical information, an AI-DSA trained to identify echocardiographic phenotype associated with an aortic valve area (AVA)<1 cm using minimal input data (excluding left ventricular outflow tract measures) was applied to routine transthoracic echocardiograms (TTE) reports from 31,141 U.
Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.
Clin Microbiol Infect
December 2024
OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:
Article Synopsis
- Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
- Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
- The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
Comparison of Pressure vs Volume Overload Ventricular Wall Stress in Patients With Valvular Heart Disease.
J Am Coll Cardiol
August 2024
Heart Centre, The Alfred Hospital, Melbourne, Victoria, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Electronic address:
Article Synopsis
- Aortic stenosis (AS) and mitral regurgitation (MR) lead to different changes in the heart's structure, and this study aimed to assess how these conditions affect left ventricular wall stress (LVWS) and cardiac remodeling.
- The study involved 47 patients with severe AS receiving transcatheter aortic valve replacement (TAVR) and 15 patients with severe MR treated with MitraClip (MC), utilizing tests like a 6-minute walk test (6MWT) and cardiac imaging to evaluate changes in LVWS before and after procedures.
- Results showed significant decreases in systolic LVWS after TAVR and diastolic LVWS after MC, with a notable correlation indicating that higher LVWS
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