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Development of an animal model of progressive vaccinia in nu/nu mice and the use of bioluminescence imaging for assessment of the efficacy of monoclonal antibodies against vaccinial B5 and L1 proteins.
Antiviral Res
August 2017
Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, USA.
Bioluminescence imaging (BLI) was used to follow dissemination of recombinant vaccinia virus (VACV) expressing luciferase (IHD-J-Luc) in BALB/c nu/nu mice treated post-challenge with monoclonal antibodies (MAbs) against L1 and B5 VACV proteins in a model of Progressive Vaccinia (PV). Areas Under the flux Curve (AUC) were calculated for viral loads in multiple organs in individual mice. Following scarification with 10 pfu, IHD-J-Luc VACV undergoes fast replication at the injection site and disseminates rapidly to the inguinal lymph nodes followed by spleen, liver, and axillary lymph nodes within 2-3 days and before primary lesions are visible at the site of scarification.
View Article and Find Full Text PDFExpanding the histologic findings in smallpox-related post-vaccinial non-viral folliculitis.
J Cutan Pathol
March 2013
Department of Dermatology, Yale University, New Haven, CT, USA.
Post-vaccinial non-viral folliculitis has been recognized in the past decade as a new adverse cutaneous reaction to smallpox vaccination. Contrary to more serious smallpox vaccine reactions, post-vaccinial non-viral folliculitis has a benign course and resolves spontaneously within approximately 7 days. We describe additional histopathologic findings associated with post-vaccinial non-viral folliculitis, which has only been described once previously.
View Article and Find Full Text PDFEvaluation of a recombinant human adenovirus-5 vaccine administered via needle-free device and intramuscular injection for vaccination of pigs against swine influenza virus.
Am J Vet Res
November 2005
USDA, National Animal Disease Center, Virus and Prion Diseases of Livestock Research Unit, Agricultural Research Service, Ames, IA 50010, USA.
Objective: To evaluate the safety and efficacy of a human adenovirus-5 vaccine for protecting weaned pigs against swine influenza virus subtype H3N2 infection when administered via 2 injection methods.
Animals: 76 pigs.
Procedure: 6 groups of weaned pigs received a 10-fold serial dilution of recombinant adenovirus expressing H3 hemagglutinin and a constant amount of recombinant adenovirus expressing nucleoprotein, either via a needle-free injection device or by traditional IM injection.
Clinical efficacy of intramuscular vaccinia immune globulin: a literature review.
Clin Infect Dis
September 2004
Dynport Vaccine Company, Frederick, Maryland, USA.
Background: Numerous literature reports describe clinical efficacy of intramuscular vaccinia immune globulin (VIG) for complications of smallpox vaccination, prophylaxis of individuals with contraindications to vaccination, and prevention of smallpox among close contacts of patients with smallpox.
Methods: We reviewed the literature regarding VIG treatment and prophylaxis of smallpox vaccine complications and the use of VIG as a preventative measure for close contacts of patients with smallpox.
Results: Data regarding intramuscular administration of VIG for treatment of smallpox vaccine complications occurred in 16 articles, none of which reported formal controlled trials.
Incidence and follow-up of inflammatory cardiac complications after smallpox vaccination.
J Am Coll Cardiol
July 2004
U.S. Army Medical Command, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA.
Objectives: The purpose of this study was to assess the follow-up of patients with vaccinia-associated myocarditis.
Background: With the threat of biological warfare, the U.S.
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