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Online monitoring of water quality in industrial wastewater treatment process based on near-infrared spectroscopy.
Water Res
January 2025
NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Shandong, Jinan 250012, China; Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, Jinan 250021, China; Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Shandong, Jinan 250012, China; Shandong Engineering Research Center for Transdermal Drug Delivery Systems, Shandong, Jinan 250098, China. Electronic address:
Water quality monitoring is one of the critical aspects of industrial wastewater treatment, which is important for checking the treatment effect, optimizing the treatment technology and ensuring that the water quality meets the standard. Chemical oxygen demand (COD) is a key indicator for monitoring water quality, which reflects the degree of organic matter pollution in water bodies. However, the current methods for determining COD values have drawbacks such as slow speed and complicated operation, which hardly meet the demand of online monitoring.
View Article and Find Full Text PDFBehavior Changes in Quinpirole Obsessive-Compulsive Disorder Rats Treated with 6-Hydroxydopamine and the Corresponding Dopaminergic Compulsive Loop Mechanism.
J Integr Neurosci
January 2025
Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, China.
Background: Recent studies suggest that the anterior limb of the internal capsule may be an area of convergence for multiple compulsion loops. In this study, the role of different dopaminergic compulsion loops in the mechanism of obsessive-compulsive disorder (OCD) was investigated by selectively damaging dopaminergic neurons or fibers in the corresponding targets with 6-hydroxydopamine (6-OHDA) and depicting the anatomical map of various compulsion loops located in the anterior limb of the internal capsule.
Methods: A total of 52 male Sprague Dawley (SD) rats were exposed to either saline (1 mL/kg, NS group, n = 6) or quinpirole (QNP, dopamine D2-agonist, 0.
Modelling Hollow Microneedle-Mediated Drug Delivery in Skin Considering Drug Binding.
Pharmaceutics
January 2025
Department of Mathematics, Visva-Bharati University, Santiniketan 731235, WB, India.
Microneedle(MN)-based drug delivery is one of the potential approaches to overcome the limitations of oral and hypodermic needle delivery. An in silico model has been developed for hollow microneedle (HMN)-based drug delivery in the skin and its subsequent absorption in the blood and tissue compartments in the presence of interstitial flow. The drug's reversible specific saturable binding to its receptors and the kinetics of reversible absorption across the blood and tissue compartments have been taken into account.
View Article and Find Full Text PDFHuman Defence Factors in Different Gestational Week Placenta: A Pilot Study.
Life (Basel)
January 2025
Institute of Anatomy and Anthropology, Riga Stradins University, Kronvalda Boulevard 9, LV-1010 Riga, Latvia.
Background: Numerous studies have shown the presence of multiple defence factors in placental tissue, although their role is partially understood; therefore, the aim of this study was to evaluate the expression of nuclear factor-kappa B (NF-κB); human beta-defensin 2, 3, and 4 (HBD-2,3,4); cathelicidine (LL-37); heat shock protein 60 (HSP60); and interleukin 10 (IL-10) in dissimilar gestational week placental tissue and display correlations between immunoreactive cells.
Methods: A total of 15 human placental tissue samples were acquired from mothers with different gestational weeks: 28, 31, and 40. Routine staining and immunohistochemistry for the samples were executed.
Plastic Creep Constraint in Nylon Instrument Strings.
Materials (Basel)
January 2025
Department of Engineering, University of Cambridge, Trumpington St, Cambridge CB2 1PZ, UK.
A number of rectified nylon harp strings, having the same nominal diameter, were subjected to different sequences of applied stress steps. Each string was tested continuously for several weeks to allow sufficient time for the stretching responses to be clearly observed. Qualitatively, much of the observed behaviour was in accordance with established expectations.
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