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Advancement from Small Peptide Pharmaceuticals to Orally Active Piperazine-2,5-dion-Based Cyclopeptides.
Int J Mol Sci
August 2023
The Laboratory of Synthetic Vaccines of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St., 16/10, Moscow 117997, Russia.
The oral delivery of peptide pharmaceuticals has long been a fundamental challenge in drug development. A new chemical platform was designed based on branched piperazine-2,5-diones for creating orally available biologically active peptidomimetics. The platform includes a bio-carrier with "built-in" functionally active peptide fragments or bioactive molecules that are covalently attached via linkers.
View Article and Find Full Text PDFProspects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome.
Russ J Bioorg Chem
October 2022
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia.
Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia and multiple organ failure. The clinical picture of COVID-19 is heterogeneous and involves most physiological systems; therefore, drugs with a wide spectrum of mechanism of action are required. The choice of the treatment strategy for post-COVID-19 syndrome is still a challenge to be resolved.
View Article and Find Full Text PDFThe effects of the new chemical substance BIV-30 on bone marrow hemopoiesis has been studied in laboratory mices on the background of myelosupression induced by a single intraperitoneal injection of cyclophosphan in a dose 160 mg/kg. The injection of BIV-30 significantly accelerated lymphocyte, monocyte, granulocyte regeneration branches of bone-marrow hemopoiesis. These results showed evidence of the hemostimulating activity of BIV-30 on the model of bone-marrow hemopoiesis deficiency.
View Article and Find Full Text PDF[Experimental study of hemostimulating properties of the tablet form of recombinant human erythropoetin].
Eksp Klin Farmakol
December 2000
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Russia.
Specific biological activity of the domestic preparation of recombinant human erythropoietin (RHEPO) in an original pill form was experimentally studied in vitro and in vivo. Administration of the RHEPO parent substance at a concentration of 0.5 10 U/ml significantly accelerated the growth of erythroid colony-forming cells (CFU-E) in the culture of intact nonadherent myelokaryocytes.
View Article and Find Full Text PDFEgg shell was used for mineral enrichment of ration for animals. Such ration exerts favourable influence on lipid, protein, and mineral metabolism, has hemostimulating and hypoallergic effects. Egg shell was recommended as a source of calcium for enrichment of different foodstuffs.
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