A multifactorial analysis of morphological findings was performed on 153 cases of medullary thyroid carcinoma (MTC). The aim of the study was to utilize histological criteria to discriminate between MTC associated with multiple endocrine neoplasia type 2A (MEN 2A) and that associated with the inherited MTC only syndrome. The presence of fusiform cells associated with several other markers seemed to be more predictive of MEN 2A. A comparison of inherited MTC only and sporadic MTC only showed fusiform cells to be significantly less common in inherited MTC only. These results suggest that the inherited MTC only syndrome is a distinct clinical and morphological entity. Further investigations are needed to confirm the findings and understand its implications.
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Article Synopsis
- - Medullary thyroid carcinoma is a rare tumor originating from parafollicular C-cells, linked to hereditary syndromes like FMTC and MEN 2, or it can occur randomly.
- - A case is reported involving a 50-year-old man diagnosed with the cancer after a neck mass was identified and examined through fine needle aspiration and histopathology.
- - Key markers for diagnosis and monitoring include carcinoembryonic antigen (CEA) and calcitonin, highlighting the importance of early detection and treatment for better survival rates.
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