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Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis.
BMC Cancer
January 2025
Department of Respiratory Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Background: Lung cancer (LC) is the leading cause of cancer-related death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNAs in LC through meta-analysis.
View Article and Find Full Text PDFPrevention strategies of esophageal stenosis after endoscopic resection for superficial esophageal cancer: a Bayesian network meta-analysis.
Int J Surg
January 2025
Department of Geriatrics, Zhongshan Hospital Xiamen University, Fujian, People's Republic of China.
Introduction: What interventions effectively prevent postoperative stenosis following endoscopic resection (ER) of superficial esophageal cancer? This study aimed to identify effective interventions or combinations through a systematic review and network meta-analysis.
Methods: Six databases were systematically searched for eligible studies up to 30 April 2023, on interventions to prevent esophageal stenosis post-ER. Odds ratios (ORs) evaluated stenosis rate (primary outcome) and complications (secondary outcome), while mean differences (MD) evaluated endoscopic balloon dilatation (EBD) sessions post-stenosis.
Acteoside alleviates salsolinol-induced Parkinson's disease by inhibiting ferroptosis via activating Nrf2/SLC7A11/GPX4 pathway.
Exp Neurol
March 2025
Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China. Electronic address:
Article Synopsis
- Salsolinol (SAL) is a neurotoxin linked to the development of Parkinson's disease (PD) by causing damage to dopaminergic neurons, and its mechanisms of toxicity involve inducing ferroptosis.
- The study utilized RNA sequencing and biochemical analysis to show that SAL decreases the levels of proteins SLC7A11 and GPX4, leading to ferroptosis in neuroblastoma cells, which can be reversed by ferroptosis inhibitors.
- Acteoside, a neuroprotective compound, counteracts SAL-induced neurotoxicity by enhancing SLC7A11 and GPX4 levels through activation of the Nrf2 pathway, suggesting a potential therapeutic strategy for PD by targeting ferroptosis.
The Role of the CPT Family in Cancer: Searching for New Therapeutic Strategies.
Biology (Basel)
November 2024
Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha 410000, China.
Along with abnormalities in glucose metabolism, disturbances in the balance of lipid catabolism and synthesis have emerged as a new area of cancer metabolism that needs to be studied in depth. Disturbances in lipid metabolic homeostasis, represented by fatty acid oxidation (FAO) imbalance, leading to activation of pro-cancer signals and abnormalities in the expression and activity of related metabolically critical rate-limiting enzymes, have become an important part of metabolic remodeling in cancer. The FAO process is a metabolic pathway that facilitates the breakdown of fatty acids into CO and HO and releases large amounts of energy in the body under aerobic conditions.
View Article and Find Full Text PDFNormal Hemodynamic Response to Exercise.
Heart Fail Clin
January 2025
Department of Public Health Department of Internal Medicine Interdepartmental Center for Gender Medicine Research (GENESIS) Cardiovascular Disease Fellowship Program Cardiovascular Pathophysiology and Therapeutics (CardioPath) Ph.D Program UNESCO Chair on Health Education and Sustainable Development Faculty of Medicine - University of Naples "Federico II", Ed. 18, I piano, Via Sergio Pansini 5, 80131 - Naples, Italy. Electronic address:
Exercise pulmonary hypertension has been invasively defined as mean pulmonary artery pressure/cardiac output slope greater than 3 mm Hg/L/min. Recent advances suggest the sustainable role of exercise Doppler echocardiography for the study of the right heart and pulmonary circulation unit (RH-PCU). Herein, the authors review the invasive versus non-invasive monitoring of the RH-PCU response to exercise in healthy subjects.
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