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Ginsenoside Rk1 exerts protective effects of LPS-induced podocyte apoptosis and inflammation by inactivating JAK2/STAT3 and NF-κB pathways.
Drug Chem Toxicol
December 2024
Internal Medicine Department, Shenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen, China.
Podocyte injury is a major biomarker of primary glomerular disease that leads to massive proteinuria and kidney failure. Ginsenoside Rk1, a substance derived from ginseng, has several pharmacological activities, such as anti-apoptotic, anti-inflammatory, and antioxidant effects. In this study, our goal is to investigate the roles and mechanisms of ginsenoside Rk1 in podocyte injury and acute kidney injury (AKI).
View Article and Find Full Text PDFNeuroprotective Potential of Ethoxzolamide Targeting Oxidative Stress and Inflammation in Experimental Models of Intracerebral Hemorrhage.
Front Biosci (Landmark Ed)
October 2024
Department of Neurosurgery, Minhang Hospital, Fudan University, 201100 Shanghai, China.
Article Synopsis
- Carbonic anhydrase inhibitors like ethoxyzolamide (ETZ) may have therapeutic benefits for central nervous system trauma, specifically intracerebral hemorrhage (ICH), but its effectiveness is still under investigation.
- Experiments using ICH models showed that ETZ improves neuronal damage and reduces inflammation and oxidative stress markers in a dose-dependent manner, while also maintaining liver and kidney function.
- The study suggests that ETZ activates the Keap1/Nrf2 pathway, enhancing antioxidant effects, by binding to the Nrf2 domain in cells affected by ICH.
Utility of Follow-Up Computed Tomography (CT) and Fluorodeoxyglucose-Positron Emission Tomography/CT (FDG-PET/CT) in Diagnosing Gastrointestinal Stromal Tumor (GIST) Presenting as Spontaneous Hemoperitoneum: A Case Report.
Cureus
September 2024
Department of Surgery, National Hospital Organization Iwakuni Clinical Center, Iwakuni, JPN.
Article Synopsis
- Spontaneous hemoperitoneum is a rare but serious condition, and gastrointestinal stromal tumors (GIST) can be a difficult-to-diagnose cause of this condition due to its infrequency.
- A 76-year-old Japanese man experienced sudden abdominal pain and was eventually diagnosed with a high-risk extraluminal gastric GIST after imaging and exploratory surgery.
- This case underscores the importance of follow-up imaging like CT and FDG-PET/CT in identifying GIST and emphasizes the necessity for surgical intervention to investigate unexplained abdominal bleeding.
A Rare Case of Diaphragmatic Rupture Due to Ectopic Pregnancy Leading to Haemorrhagic Shock in a Multipara: A Case Report.
Int J Womens Health
October 2024
Department of Gynecology, Hainan Western Central Hospital, Danzhou City, Hainan Province, People's Republic of China.
Article Synopsis
- - Abdominal pregnancy is a rare and severe form of ectopic pregnancy, with risk factors including pelvic inflammatory disease and past surgeries or pregnancies.
- - A case report describes a 21-year-old woman with severe abdominal pain and signs of shock due to a ruptured hemidiaphragm from ectopic pregnancy.
- - Emergency surgery showed significant internal bleeding, but after treatment, the patient recovered, emphasizing the need to consider diaphragmatic rupture in similar medical emergencies.
Giant gastrointestinal stromal tumor resulting in intra-abdominal bleeding after failure of imatinib treatment, case report.
Int J Surg Case Rep
November 2024
General Surgery Department, Alnoor Specialist Hospital, Mecca, Saudi Arabia. Electronic address:
Article Synopsis
- Gastrointestinal tumors (GIST) are soft tissue tumors often found in the stomach, classified based on their location, size, and growth rate.
- A 40-year-old woman was diagnosed with GIST after abdominal pain and underwent treatment with imatinib, but experienced severe complications leading to emergency surgery due to massive internal bleeding.
- The case highlights that while chemotherapy can help, surgical intervention may be necessary, especially for larger GISTs, due to the high risk of complications.
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