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[Role of interaction between reactive oxygen species and ferroptosis pathway in methylglyoxal-induced injury in mouse embryonic osteoblasts].
Nan Fang Yi Ke Da Xue Xue Bao
January 2022
Department of Endocrinology, East Ward of Guangdong Geriatric Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Objective: To explore the interaction between reactive oxygen species (ROS) and ferroptosis in methylglyoxalinduced injury of mouse embryonic osteoblasts (MC3T3-E1 cells).
Methods: MC3T3-E1 cells were treated with methylglyoxal to establish a cell model of diabetic osteoporosis. CCK-8 assay was used to detect the viability of MC3T3-E1 cells.
[Interaction between glycogen synthase kinase-3β and endoplasmic reticulum stress is involved in high glucose-induced injury in human umbilical vein endothelial cells].
Nan Fang Yi Ke Da Xue Xue Bao
May 2018
Department of Internal Medicine, Huangpu Division of First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510700, China.E-mail:
Objective: To explore the role of the interaction between glycogen synthase kinase-3β (GSK-3β) and endoplasmic reticulum stress (ERS) in the high glucose (HG)-induced injury in human umbilical vein endothelial cells (HUVECs).
Methods: HUVECs treated with 40 mmol/L glucose for 24 h were examined for expression levels of GSK-3β, GRP78, CHOP and cleaved caspase-3 protein using Western blotting. The cell viability was examined using CCK-8 assay and cell apoptosis was detected with Hoechst 33258 nuclear staining and photofluorography.
Endoscopy in screening for digestive cancer.
World J Gastrointest Endosc
December 2012
René Lambert, World Health Organization International Agency for Research on Cancer, Screening Group, Lyon 69372, France.
The aim of this study is to describe the role of endoscopy in detection and treatment of neoplastic lesions of the digestive mucosa in asymptomatic persons. Esophageal squamous cell cancer occurs in relation to nutritional deficiency and alcohol or tobacco consumption. Esophageal adenocarcinoma develops in Barrett's esophagus, and stomach cancer in chronic gastric atrophy with Helicobacter pylori infection.
View Article and Find Full Text PDFThe role of digital technologies to decrease the radiation exposure from X-ray diagnostics to the population of Ukraine.
Radiat Prot Dosimetry
August 2010
Center of X-Ray technologies of ARU, Kyiv, Ukraine.
Over 40 % of the collective dose to the population of Ukraine is due to prophylactic photofluorography. The transition to digital technologies in X-ray diagnostics allows not only one to raise efficiency of X-ray examinations, but also to reduce the radiation exposure to the population. Based on statistical data about the X-ray systems available today, the present study indicates that replacement of all photofluorography by digital chest radiography has the potential of decreasing the collective dose to the population in Ukraine by more than 30 %.
View Article and Find Full Text PDFBinaral interaction and centrifugal input enhances spatial contrast in olfactory bulb activation.
Eur J Neurosci
January 2007
Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.
We used paired-pulse odorant stimulation, with a conditioning stimulus delivered either ipsilateral or contralateral to a test stimulus, to unmask the effects of centrifugal feedback on olfactory bulb responses. In reptiles and mammals there are no direct connections between the paired olfactory bulbs, and thus all information transfer between the olfactory bulbs depends on feedback from retrobulbar structures. We measured odor-induced activity in the turtle olfactory bulb using a voltage-sensitive dye and a 464-element photodiode array, which allowed us to monitor the spatial variation in activation of the olfactory bulb.
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