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The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy.
Stem Cell Res Ther
January 2025
Department of Physiology, University of Seville, Seville, Spain.
Introduction: Neural stem cells from the subventricular zone (SVZ) neurogenic niche provide neurons that integrate in the olfactory bulb circuitry. However, in response to cortical injuries, the neurogenic activity of the SVZ is significantly altered, leading to increased number of neuroblasts with a modified migration pattern that leads cells towards the site of injury. Despite the increased neurogenesis and migration, many newly generated neurons fail to survive or functionally integrate into the cortical circuitry.
View Article and Find Full Text PDFThe anillin knockdown in the Drosophila nervous system shows locomotor and learning defects.
Exp Cell Res
November 2024
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan. Electronic address:
Anillin (Ani) is an evolutionarily conserved protein with a multi-domain structure that cross-links cytoskeletal proteins and plays an essential role in the formation of the contractile ring during cytokinesis. However, Ani is highly expressed in the human central nervous system (CNS), and it scaffolds myelin in the CNS of mice and modulates neuronal migration and growth in Caenorhabditis elegans. Although Ani is also highly expressed in the Drosophila CNS, its role remains unclear.
View Article and Find Full Text PDFSwitching of RNA splicing regulators in immature neuroblasts during adult neurogenesis.
Elife
November 2024
Université Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRP/iRCM, Fontenay-aux-Roses, France.
The lateral wall of the mouse subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular profiling at the single-cell level struggles to distinguish these different cell types. Here, we combined transcriptome analyses of FACS-sorted cells and single-cell RNAseq to demonstrate the existence of an abundant, clonogenic and multipotent population of immature neuroblasts (iNB cells) at the transition between TAP and migrating NB (mNB).
View Article and Find Full Text PDFAcentric chromosome congression and alignment on the metaphase plate via kinetochore-independent forces in Drosophila.
Genetics
November 2024
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 1156 High Street Santa Cruz, CA, 95064, USA.
Chromosome congression and alignment on the metaphase plate involves lateral and microtubule plus-end interactions with the kinetochore. Here we take advantage of our ability to efficiently generate a GFP-marked acentric X chromosome fragment in Drosophila neuroblasts to identify forces acting on chromosome arms that drive congression and alignment. We find acentrics efficiently congress and align on the metaphase plate, often more rapidly than kinetochore-bearing chromosomes.
View Article and Find Full Text PDFWhat is the neurobiology of schizophrenia?
CNS Spectr
October 2024
University of California, San Diego, CA, USA.
Article Synopsis
- * These disorders are heavily influenced by genetics (about 80%), with many genes linked to brain development, and also involve environmental factors (about 20%), leading to structural brain abnormalities and psychosis.
- * Antipsychotic medications can help reduce symptoms, especially acute psychosis, but primarily slow disease progression rather than reverse it; long-acting treatments are more effective, with clozapine being the top choice for treatment-resistant cases.
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