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This review presents a detailed definition of gastroesophageal reflux disease (GERD) and data on its prevalence, etiological and pathogenetic factors. The clinical picture of the disease, its clinical “masks” and complications including Barrett’s oesophagus and oesophageal carcinoma are discussed. Various diagnostic methods, such as oesophagofibroscopy, targeted biopsy, morphological studies, multichannel 24 hr pH-metry, etc.
View Article and Find Full Text PDF[Extranodal diffuse large B-cell lymphoma--an organotypic disease?].
Pathologe
February 2007
Institut für Pathologie, Julius-Maximilians-Universität Würzburg.
Roughly 30-40% of diffuse large B-cell lymphomas (DLBCL) arise primarily in extranodal sites. Most frequently, they occur in the gastrointestinal tract, especially in the gastric mucosa. They also occur in the central nervous system, as testicular lymphomas, in the lungs, or in the skin.
View Article and Find Full Text PDFHigh-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.
Cancer Cell
April 2006
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolution analysis of recurrent copy number alterations (CNAs) and expression profiles in a collection of MM cell lines and outcome-annotated clinical specimens. Attesting to the molecular heterogeneity of MM, unsupervised classification using nonnegative matrix factorization (NMF) designed for array comparative genomic hybridization (aCGH) analysis uncovered distinct genomic subtypes. Additionally, we defined 87 discrete minimal common regions (MCRs) within recurrent and highly focal CNAs.
View Article and Find Full Text PDFClinical pathogenetic classification is based on the results of many-year observation of a large group of patients in whom the tuberculous etiology of ocular disease was confirmed by a universal approach based on reliable informative diagnostic criteria. Three pathogenetic and 4 clinical forms of ocular tuberculosis were distinguished. The classification for the first time includes ocular involvement in tuberculosis of the central nervous system and tuberculosis of defense system of the eye.
View Article and Find Full Text PDF[Clinico-pathogenetic variants of DIC syndrome in patients with severe craniocerebral trauma].
Anesteziol Reanimatol
September 1999
Detection of clinical and pathogenetic variants of the DIC syndrome for development of its differentiated therapy in multiple-modality treatment of severe craniocerebral injury was the purpose of this study. A total of 170 patients with grave craniocerebral injury were examined. The hemostasis system was studied by the following methods: analysis of platelet hemostasis, general coagulation tests, fibrinolysis evaluation, detection of physiological anticoagulants and markers of intravascular blood coagulation and fibrinolysis.
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