AI Article Synopsis
- Trimethoxybenzoyl-glycine-diethylamide led to normal sleep in dogs and cats without causing loss of coordination (ataxia) beforehand.
- Increasing the dose five- to ten-fold resulted in restlessness and disorientation rather than promoting sleep.
- In humans, doses between 500 to 1500 mg caused sedation or drowsiness in about half the subjects, with no significant EEG disturbances observed.
Article Abstract
Trimethoxybenzoyl-glycine-diethylamide induced in dogs and cats normal sleep without preceding ataxia. A five- to ten-fold increase of the soporific dose resulted in restlessness and disorientation instead of sleep. In man, oral doses of 500 to 1500 mg caused sedation or drowsiness, or both, in half the cases. No spindling or drug-induced artifacts were found in electroencephalographic recordings.
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| http://dx.doi.org/10.1126/science.128.3338.1570 | DOI Listing |
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