[Interactions between GABAergic and cholinergic mechanisms involved in monocular optokinetic nystagmus in frogs].

C R Acad Sci III

Laboratoire de Neurophysiologie et Biologie des Comportements, U.P.R. n. 419 du C.N.R.S., Strasbourg.

Published: January 1993

The systemic administration of atropine, a muscarinic cholinergic antagonist, was found to suppress the Nasal-Temporal (N-T) component of the frog monocular optokinetic nystagmus (OKN), which had appeared following a prior injection of bicuculline and which does not exist in the normal animal. On the contrary, the administration of a nicotinic cholinergic antagonist (D-TC, alpha-BGT, Hexamethonium) following that of bicuculline has prolonged the duration of the induced N-T component. Thus, ACh was shown to attenuate or to reinforce the GABAergic inhibition of the N-T component through muscarinic receptors or nicotinic receptors respectively. These data point to the existence of strong interactions between these two neurotransmission systems involved in frog monocular OKN.

Download full-text PDF

Source

Publication Analysis

Top Keywords

n-t component
12
monocular optokinetic
8
optokinetic nystagmus
8
cholinergic antagonist
8
frog monocular
8
[interactions gabaergic
4
gabaergic cholinergic
4
cholinergic mechanisms
4
mechanisms involved
4
involved monocular
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!