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Secretogranin III: a promising therapeutic target for intraocular neovascular lesions.
Int Ophthalmol
January 2025
Department of Ophthalmology, The Second Hospital of Jilin University, #218 Ziqiang Street, Changchun, 130041, Jilin, China.
Purpose: The purpose of this study is to investigate the role of Secretogranin III (Scg3) in the pathogenesis of intraocular neovascular diseases and assess its potential as a therapeutic target for novel treatment strategies.
Methods: A literature review was conducted to examine the expression of Scg3 in intraocular neovascular diseases. We reviewed studies on the interaction of Scg3 with its homologous receptors and its effect on endothelial cell proliferation, migration, and vascular permeability-key processes involved in angiogenesis and neovascularization.
Analysis of Platelet Morphological Parameters as Clinical Risk Stratification in Acute Coronary Syndrome.
Catheter Cardiovasc Interv
January 2025
Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
Background: Platelet activation plays a central role in the pathogenesis of acute coronary syndrome (ACS). Platelet morphological parameters, including MPV, PDW, and P-LCR, are emerging as biomarkers for predicting the severity of ACS and prognosis.
Aims: This study aims to assess the relationship between these parameters and coronary severity and to evaluate their predicting adverse outcomes.
C5a/C5aR regulates Th1/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression.
Ann Med
December 2025
Department of Emergency, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Objective: Multi-organ failure frequently complicates sepsis, with lungs being the primary target. T helper (Th) cell activation and phenotypic imbalance among them contribute significantly to sepsis-associated lung injury. Additionally, the complement system could regulate the polarized phenotype of T lymphocytes.
View Article and Find Full Text PDF[Neuroimaging predictors of hemorrhagic transformation of ischemic stroke].
Zh Nevrol Psikhiatr Im S S Korsakova
January 2025
Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia.
Hemorrhagic transformation (HT) is a serious complication that worsens outcomes and increases mortality in patients with ischemic stroke (IS). HT can occur both spontaneously and after reperfusion therapy. Severe ischemic injury in IS is not sufficient in itself to cause HT; one of the key elements in its development is reperfusion.
View Article and Find Full Text PDF[Clinical and tomographic comparisons in patients with aphasia in the acute period of ischemic stroke].
Zh Nevrol Psikhiatr Im S S Korsakova
January 2025
Vladimirskii Moscow Regional Research and Clinical Institute, Moscow, Russia.
Objective: To investigate the structural damage in patients with aphasia in the acute phase of ischemic stroke using X-ray computed tomography (CT) scans of the brain.
Material And Methods: We examined 65 right-handed individuals in the acute stage of ischemic stroke in the left middle cerebral artery, including 39 men and 26 women aged 41 to 87 years. The patients were divided into two groups: those with aphasia (group 1, 48) and those without aphasia (group 2, 17).
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