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Article Synopsis
  • Hypoglycemia is frequently seen in diabetic patients, often caused by medications, but can also stem from other health issues, as demonstrated by a case of acute hypopituitarism due to pituitary apoplexy.
  • A 45-year-old male diabetic patient presented with severe hypoglycemia and changes in mental state, leading to the discovery of a pituitary macroadenoma with hemorrhage through brain imaging.
  • Management should consider the potential for rare causes like hypopituitarism when patients with diabetes exhibit severe hypoglycemia and altered mentation, indicating possible cortisol deficiency.
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Recurrent Cushing's Disease Caused by a TPIT-Lineage Densely Granulated Corticotroph Pituitary Neuroendocrine Tumor: A Case Report.

Neuro Endocrinol Lett

January 2024

Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.

Introduction: Recurrent Cushing's disease (recurrent CD) is an uncommon and intricate clinical form of Cushing's syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain.

Case Description: A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain.

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Intraoperative bleeding poses a substantial challenge, particularly in neuro-spine surgeries leading to complications such as hematomas, infections, and hemodynamic instability. Despite their proven efficacy, use of topical hemostatic agents (THAs) lacks comprehensive published literature and guidelines particularly in the Indian setting. The present study provides the first-ever Indian expert panel recommendations for effective adjunct THA use in different intraoperative bleeding sites and situations in neuro-spine surgeries.

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Retained foreign bodies are foreign materials which are left accidentally inside a patient's body after a procedure. In this report we present the case of a 57 year old man who presented to the ENT clinic with a history of symptoms stretching over 8 years back to when he underwent a hypophysectomy through the transsphenoidal approach. These symptoms included cacosmia, ageusia, altered taste at times, foul smelling discharge, nasal discharge and dizziness.

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Ectopic sphenoidal ACTH-secreting adenoma revealed by C Methionine PET scan: case report.

BMC Endocr Disord

February 2023

Endocrinology and Nutrition Department, Cliniques Universitaires Saint-Luc, n°10, Avenue Hippocrate, 1200, Brussels, Belgium.

Background: Ectopic ACTH pituitary adenomas (EAPA), located outside the sella turcica and deriving from cellular remnants of Rathke's pouch are a very rare cause of Cushing's syndrome (CS). The diagnosis is often difficult and delayed, even after comprehensive work-up. To our knowledge, we report for the first time an ectopic corticotroph tumor of the posterior wall of the sphenoid sinus, leading to false positive results of bilateral inferior petrosal sinus sampling (BIPPS) and which was finally localized by a co-registered C Methionine PET/MR imaging.

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