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Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival.
Science
January 2025
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, suggesting separate mechanisms are involved. Here, we found that the transcription factor Casz1 was crucial for early IHC fate consolidation and for OHC survival during mouse development. Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production.
View Article and Find Full Text PDFSox2 interacts with Atoh1 and Huwe1 Loci to regulate Atoh1 transcription and stability during hair cell differentiation.
PLoS Genet
January 2025
Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, United States of America.
Stem cell pluripotency gene Sox2 stimulates expression of proneural basic-helix-loop-helix transcription factor Atoh1. Sox2 is necessary for the development of cochlear hair cells and binds to the Atoh1 3' enhancer to stimulate Atoh1 expression. We show here that Sox2 deletion in late embryogenesis results in the formation of extra hair cells, in contrast to the absence of hair cell development obtained after Sox2 knockout early in gestation.
View Article and Find Full Text PDFEvaluation of the Nijmegen Cochlear Implant Questionnaire in Danish.
Int Arch Otorhinolaryngol
January 2025
Research Unit for ORL - Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.
The Nijmegen cochlear implant questionnaire (NCIQ) is a quantifiable self-assessment health-related quality of life (HRQoL) tool used internationally to determine quality of life (QoL) in cochlear implant (CI) users and to evaluate the implant's subjective benefits. This study aimed to validate the Danish version of the questionnaire (DA-NCIQ) with a test-retest including 60 participants (30 CI users and 30 CI candidates). The intraclass correlation coefficients (ICC) were calculated to evaluate the temporal stability of the participants' answers and the internal consistency of the questionnaire domains was determined using the Cronbach alpha in order to compare these results with the NCIQ's other language versions.
View Article and Find Full Text PDFIntroduction: This study aims to investigate the impact of auditory input on postural control in young adult cochlear implant users with profound sensorineural hearing loss. The research explores the relationship between auditory cues and static postural stability in individuals with hearing impairment.
Methods: 34 young adult cochlear implant users, consisting of 15 males and 19 females aged 18-35 years, underwent various balance tests, including the modified Clinical Tests of Sensory Interaction on Balance (mCTSIB) and the Unilateral Stance Test (UST), under different auditory conditions: (1) White noise stimulus present with the sound processor activated, (2) Ambient noise present with the sound processor activated, and (3) Sound processor deactivated.
Long-Term Clinical Outcomes for Bone-Anchored Hearing Implants: 3-Year Comparison Between Minimally Invasive Ponto Surgery and the Linear Incision Technique With Tissue Preservation.
Otol Neurotol
February 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Donders Center for Neuroscience, Radboud University Medical Center, Radboud University, Nijmegen, the Netherlands.
Objective: To compare the 3-year outcomes of the modified minimally invasive Ponto surgery (m-MIPS) to both the original MIPS (o-MIPS) and linear incision technique with soft tissue preservation (LIT-TP) for inserting bone-anchored hearing implants (BAHIs).
Study Design: Prospective study with three patient groups: m-MIPS, o-MIPS, and LIT-TP.
Setting: Tertiary referral center.
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