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Assessing the safety of increased outpatient cephalosporin use following the modification of penicillin allergy cross-reactivity alerts.
Infect Control Hosp Epidemiol
March 2025
Department of Pharmaceutical Care, University of Iowa Health Care, Iowa City, IA, USA.
Background: Concerns about penicillin-cephalosporin cross-reactivity have historically led to conservative prescribing and avoidance of cephalosporins in patients with penicillin allergy labels, potentially causing suboptimal outcomes. Recent evidence suggests a lower risk of cross-reactivity, prompting a reassessment of alert systems.
Objective: To assess the impact of limited penicillin cross-reactivity alerts on outpatient cephalosporin use and the incidence of adverse reactions in a healthcare setting.
Inorganic Nanomaterials Meet the Immune System: An Intricate Balance.
Adv Healthc Mater
March 2025
Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano 4, Genoa, 16148, Italy.
The immune system provides defense against foreign agents that are considered harmful for the organism. Inorganic nanomaterials can be recognized by the immune system as antigens, inducing an immune reaction dependent on the patient's immunological anamnesis and from several factors including size, shape, and the chemical nature of the nanoparticles. Furthermore, nanomaterials-driven immunomodulation might be exploited for therapeutic purposes, opening new horizons in oncology and beyond.
View Article and Find Full Text PDFAllergic Reaction to Beta-Glucans in an Obese Dog: A Case Report of Confirmed and Suspected Sources.
J Anim Physiol Anim Nutr (Berl)
March 2025
Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, Pet Nutrology Research Center, University of Sao Paulo, Sao Paulo, Brazil.
Food allergy is defined as an abnormal immune system response to the ingestion of certain ingredients or food additives. Beta-glucans may support the management of obesity, particularly due to their immunomodulatory properties. However, the possible adverse reactions of this nutraceutical are little known.
View Article and Find Full Text PDFThe prevalence of peanut-triggered food protein-induced enterocolitis syndrome in a prospective cohort of infants introducing peanut in the first year of life.
Pediatr Allergy Immunol
March 2025
Department of Pediatrics, Reinier de Graaf Hospital, Delft, The Netherlands.
Background: Since the early introduction of peanut to prevent IgE-mediated peanut allergy, other case series have suggested an increased incidence of peanut-triggered Food Protein Induced Enterocolitis Syndrome (FPIES). Data on the prevalence of peanut-induced FPIES in prospective cohorts are lacking.
Methods: The PeanutNL cohort is a prospective cohort that included infants at risk of peanut allergy (n = 706) as well as infants with reactions to peanut at home after early introduction (n = 186).
The Late Asthmatic Reaction Is in Part Independent from the Early Asthmatic Reactions.
Int J Mol Sci
February 2025
Department of Pediatrics, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
House dust mites (HDM) are the world's most important cause of allergic asthma. It is unclear why some patients with HDM allergy develop an early asthmatic reaction (EAR) only, whereas others react with a dual asthmatic reaction-EAR plus late asthmatic reaction (LAR). In patients with LAR, the symptoms and bronchial inflammation are more severe, and the current knowledge suggests that the EAR always precedes the LAR.
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