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Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages.
Molecules
December 2024
Department of Life Sciences, Kyonggi University, Suwon 16227, Republic of Korea.
Quercetin is a natural polyphenolic flavonoid widely found in plants, fruits, and vegetables, and has been reported to play pharmacological roles in numerous pathogenic conditions. The anti-inflammatory effects of quercetin in various inflammatory conditions and diseases have been well-documented. However, its regulatory role in noncanonical inflammasome activation has not yet been demonstrated.
View Article and Find Full Text PDFEnhanced solubility, stability, bioaccessibility, and antioxidant activity of curcumin with hydrolyzed pea protein-based nano-micelles: pH-driven method vs ethanol-induced method.
Int J Biol Macromol
December 2024
School of Public Health, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China. Electronic address:
Pea protein nano-micelles gained with partial hydrolysis by a proteolytic enzyme (Protamex) were employed as nanocarriers to encapsulate and stabilize liable and hydrophobic curcumin (CUR) with two various methods (pH-driven method (PDM) and ethanol-induced method (EIM)). Both CUR-loaded pea protein hydrolysates (PPHs) nano-micelles by PDM and EIM exhibited spherical shapes, and uniform particle size distributions. Highest CUR loading amount (3.
View Article and Find Full Text PDFIs Bacillus cytotoxicus from edible insects a threat?
Int J Food Microbiol
February 2025
Department of Comparative Biomedicine and Food Science, University of Padua, Viale Università 16, 35020 Legnaro, Pd, Italy.
Bacillus cytotoxicus is considered a potential emerging foodborne pathogen that has been under investigation in recent years. Most studies have focused on strains from vegetables, particularly potato products, but there is limited information on strains from other food sources. This study addresses the current research gap by investigating the genomic and phenotypic features of B.
View Article and Find Full Text PDFFrom Beer to Cheese: Characterization of Caseinolytic and Milk-Clotting Activities of Proteases Derived from Brewer's Spent Grain (BSG).
Foods
November 2024
Biological Research Institute, National Scientific and Technical Research Council (CONICET), University of Mar del Plata (UNMDP), Mar del Plata 7600, Argentina.
Article Synopsis
- - The study investigates proteolytic enzymes extracted from brewer's spent grain (BSG) sourced from various artisanal beers, assessing their ability to serve as eco-friendly coagulants in cheese-making.
- - Through optimization experiments, the researchers identified that caseinolytic activity peaked at pH 8.0, with significant variations in enzyme efficacy across different BSG samples.
- - Results suggest that certain BSG extracts possess milk-clotting activity comparable to traditional plant-based coagulants, indicating a promising sustainable connection between the brewing and dairy sectors.
Releasing a sugar brake generates sweeter tomato without yield penalty.
Nature
November 2024
National Key Laboratory of Tropical Crop Breeding, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
In tomato, sugar content is highly correlated with consumer preferences, with most consumers preferring sweeter fruit. However, the sugar content of commercial varieties is generally low, as it is inversely correlated with fruit size, and growers prioritize yield over flavour quality. Here we identified two genes, tomato (Solanum lycopersicum) calcium-dependent protein kinase 27 (SlCDPK27; also known as SlCPK27) and its paralogue SlCDPK26, that control fruit sugar content.
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