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Effects of paclitaxel and methotrexate associated with cholesterol-rich nanoemulsions on ischemia-reperfusion injury after unilateral lung transplantation in rats.
Sci Rep
December 2024
Laboratorio de Pesquisa em Cirurgia Toracica, Departamento de Cardiopneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Currently, the barrier to successful lung transplantation is ischemia and reperfusion injury, which can lead to the development of bronchiolitis obliterans. Paclitaxel and methotrexate are drugs known to inhibit cell proliferation and have anti-inflammatory effects, and the association of these drugs with cholesterol-rich nanoparticles has been shown to be beneficial in the treatment of other transplanted organs. Thirty-three male Sprague Dawley rats were divided into 3 groups: Basal group, no intervention; Control group, received only nanoparticles; Drug group, paclitaxel and methotrexate treatment.
View Article and Find Full Text PDFAn Optimized and Sensitive UHPLC-ESI-Q-TOF/HRMS Demonstrated the Dynamic Profiling of Allantoin, N-trans-Feruloyl-3-Methoxytyramine, and N-p-Coumaroyltyramine from Portulaca oleracea L. In Vivo in Rats.
J Sep Sci
January 2025
School of Pharmaceutical Sciences and Yunnan Provincial Key Laboratory of Pharmacology for Natural Medicines, Kunming Medical University, Kunming, Yunnan, People's Republic of China.
This study revealed the dynamic profiling of three main components of Portulaca oleracea L. in vivo in rats, namely allantoin (A), N-trans-feruloyl-3-methoxytyramine (M), and N-p-coumaroyltyramine (C). A sensitive and efficient UHPLC-ESI-Q-TOF/HRMS, including an optimized separation process, was applied to their qualitative and quantitative analysis.
View Article and Find Full Text PDFEffects of extract supplementation on growth performance, carcass traits, antioxidant capacity, immunity and meat quality of meat ducks.
Front Vet Sci
December 2024
Institute of Animal Husbandry and Veterinary Science, Jiangxi Academy of Agricultural Sciences, Nanchang, China.
Article Synopsis
- GPE extract from traditional Chinese medicine shows promise in enhancing growth performance and meat quality in ducks.
- The study involved 480 ducks receiving different levels of GPE over 7 weeks, with the highest dosage (600 mg/kg) leading to significant health benefits.
- Findings indicated improvements in serum antioxidant capacity, immune function, and meat characteristics like moisture content and tenderness, suggesting GPE could be a viable alternative to antibiotics in poultry farming.
Constructing a green modifier by using glyoxal-urea resin and chitosan to obtain a modified soy protein adhesive with high bonding strength and excellent water resistance.
Int J Biol Macromol
December 2024
Yunnan Key Laboratory of Wood Adhesives and Glue Products, Southwest Forestry University, Kunming 650224, PR China; College of Materials and Chemical Engineering, Southwest Forestry University, Kunming 650224, PR China. Electronic address:
The manufacturing of soy-based adhesives with high bonding strength, excellent water resistance, and exceptional environmental performance still faces difficulties. In this work, using glyoxal-urea (GU) resin, chitosan (CS), and soy protein isolate (SPI) as the primary raw materials in order to effectively mitigate the release of free formaldehyde commonly found in traditional wood-based panels. Obtaining an adhesive with high strength, excellent water resistance, and a stable cross-linking structure of GU/CS/SPI (CS represents different mass fractions of chitosan solution).
View Article and Find Full Text PDFCombined effects of and on ameliorating cisplatin-induced nephrotoxicity in Swiss albino mice.
Nat Prod Res
December 2024
Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, National University, Cheongju, Chung Buk, Republic of Korea.
and are renowned for their medicinal properties and rich antioxidant content. These plants have been integral to Ayurvedic medicine, treating various ailments for centuries. The present study investigated the nephroprotective effects of aqueous methanolic extracts of and in a Cisplatin-induced rodent model.
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