The values of the absolute eosinophil count in certain laboratory animals were examined and were compared with values in healthy humans. The method and the results extend the possibility of detecting and studying changes in biological processes in the organism of experimental animals.
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BMC Public Health
January 2025
Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapi Road, Niaosong Township, Kaohsiung County 833, Kaohsiung City, Taiwan.
Background: Asthma is a common respiratory disease in children, and air pollution is a risk factor for pediatric asthma. However, how air pollution affects blood cells in pediatric patients with asthma remains unclear.
Methods: This retrospective observational study, performed in 2007-2018 at a medical center, enrolled non-trauma patients aged < 17 years who visited the emergency department and had asthma.
Vet Parasitol Reg Stud Reports
January 2025
Animal Genetics and Breeding Division, ICAR-Central Sheep and Wool Research Institute, Avikanagar 304 501, Rajasthan, India.
A strong Th2-type immune response against Haemonchus contortus infection in genetically resistant sheep provide immunity. The objective of present study was to correlate mean faecal egg counts (FECs), absolute eosinophil counts and Th1/Th2 gene expression in resistant (R) and susceptible (S) Malpura sheep. In spite of no anthelmintic treatment in R line, on majority of the months, mean FECs remained significantly (P < 0.
View Article and Find Full Text PDFClin Transl Gastroenterol
January 2025
Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA.
Introduction: We assessed potential mechanisms behind the requirement for more frequent dupilumab dosing in eosinophilic esophagitis (EoE) compared with other approved indications.
Methods: Results for the phase 3 LIBERTY EoE TREET study coprimary endpoints (proportion of patients achieving a peak intraepithelial eosinophil count of ≤6 eosinophils per high-power field and absolute change from baseline in Dysphagia Symptom Questionnaire total score) were pooled in exposure-response analyses.
Results: A steep initial relationship then plateau was observed between higher dupilumab steady-state trough concentrations and decreased eosinophilic infiltration at week 24, whereas a graded exposure-response relationship was observed for symptomatic improvement at week 24.
J Allergy Clin Immunol Glob
February 2025
Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Cincinnati, Ohio.
Background: Omalizumab (OMA), a recombinant humanized IgG monoclonal anti-IgE antibody, is approved for treatment for chronic spontaneous urticaria (CSU) refractory to second-generation H-antihistamine (SGAH) therapy. However, currently, there are no validated serum biomarkers to reliably predict response to OMA treatment.
Objective: We explored the real-world clinical utility of using serum biomarkers for predicting response to OMA for CSU patients with disease refractory to high-dose SGAH therapy.
Hematology
December 2025
Department of Pediatrics, Peking University First Hospital Ningxia Women and Children's Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital), Yinchuan, People's Republic of China.
Background: This study aimed to develop a prognostic model based on extracellular trap-related genes (NETRGs) for patients with cALL.
Methods: Data from the TARGET-ALL-P2 and TARGET-ALL-P3 cohorts in the Genomic Data Commons database, the transcriptome dataset GSE26713, the single-cell transcriptome dataset GSE130116 from the Gene Expression Omnibus database and 306 NETRGs identified were analysed. Differentially expressed genes (DEGs) were identified from GSE26713 and differentially expressed NETRGs (DE-NETRGs) were obtained by overlapping DEGs with NETRGs.
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