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Introduction: Sarcomas are rare cancers originating from mesenchymal tissues, manifesting in diverse anatomical locations, but notably in connective tissue, muscles and the skeleton. Thoracic sarcomas present a unique diagnostic and surgical challenge attributable to their rarity and pathoanatomy. Standard practice currently comprises wide surgical excision, often accompanied by adjuvant chemotherapy and/or radiotherapy.
View Article and Find Full Text PDFProlonged screen time is associated with increased severity of tic symptoms in children with tic disorders.
Ital J Pediatr
January 2025
Department of developmental and behavior pediatrics, Children's Medical Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Background: Recent studies have emphasized the association between prolonged screen exposure and neurodevelopmental disorders, though its correlation with tic disorders (TDs) remains ambiguous. We thus conducted this study to investigate the association between screen time (ST) and the severity of tic symptoms in children diagnosed with TDs.
Methods: We conducted a retrospective case-control study with 342 cases of TDs and 270 controls, collecting data from March 2021 to December 2023.
External validation of a multivariable prediction model for positive resection margins in breast-conserving surgery.
BMC Res Notes
January 2025
Department of Surgery, Department of Clinical Sciences, Division of Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
Objectives: Positive resection margins after breast-conserving surgery (BCS) most often demands a repeat surgery. To preoperatively identify patients at risk of positive margins, a multivariable model has been developed that predicts positive margins after BCS with a high accuracy. This study aimed to externally validate this prediction model to explore its generalizability and assess if additional preoperatively available variables can further improve its predictive accuracy.
View Article and Find Full Text PDFIntegrating mitochondrial and lysosomal gene analysis for breast cancer prognosis using machine learning.
Sci Rep
January 2025
Departments of Breast Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu, People's Republic of China.
The impact of mitochondrial and lysosomal co-dysfunction on breast cancer patient outcomes is unclear. The objective of this study is to develop a predictive machine learning (ML) model utilizing mitochondrial and lysosomal co-regulators in order to provide a foundation for future studies focused on breast cancer (BC) patients' stratification and personalized interventions. Firstly, Differences and correlations of mitochondrial and lysosome related genes were screened and validated by differential analysis, copy number variation (CNV), single nucleotide polymorphism (SNPs) and correlation analysis.
View Article and Find Full Text PDFUsing evidence-based imaging referral guidelines to facilitate appropriate imaging: Are they all the same?
Eur J Radiol
January 2025
Radiography and Diagnostic Imaging, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Rationale And Objectives: Countries worldwide have selected, adopted, adapted, and translated evidence-based imaging referral guidelines from radiology professional bodies. This study establishes the concordance of three imaging referral guidelines from the ACR, ESR, and RCR, and examines the emergency department cervical spine imaging appropriateness rates.
Materials And Methods: A retrospective analysis of the electronic medical records was performed between October 1st to December 31st, 2022, evaluating 452 radiography and 153 CT imaging referrals.
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