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Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis.
J Nanobiotechnology
January 2025
Department of Pharmacy The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, coupled with the release of proinflammatory factors, indicating the potential as a viable approach of inducing anti-tumor immune activation.
View Article and Find Full Text PDFCollaborative control technology and application of support and modification for soft-rock roadway in a kilometer-deep coal mine.
Sci Rep
January 2025
School of Mine Safety, North China Institute of Science and Technology, Langfang, 065201, China.
The soft-rock roadways in kilometer-deep coal mines are often damaged by large deformation and have to be periodically expanded and repaired, which seriously restricts the safe and efficient production of coal mines. A typical soft-rock roadway in a kilometer-deep coal mine is selected as the engineering, and the main reasons for roadway deformation are analyzed, and the ground stress and mechanical characteristics are obtained. The Flac numerical model, which can accurately reflect the deformation characteristics of surrounding rock in kilometer-deep soft-rock roadway, has been constructed, and the evolution laws of stress field and its damage mechanism have been analyzed with the vertical stress, vertical displacement and plastic zone.
View Article and Find Full Text PDFAdiponectin removal by the human kidney: A preliminary study.
Nutr Metab Cardiovasc Dis
November 2024
Department of Internal Medicine, Genoa University, Italy.
Background And Aims: The adipocyte-derived adiponectin (APN) has potent insulin-sensitizing and anti-inflammatory properties. The adipose tissue is known to be the main source for APN in the circulation, but sites and mechanisms which remove APN from blood are still unknown in humans.
Methods And Results: We reviewed APN data obtained in previous studies in which the inter-organ exchange of amino acids and cytokines was measured in our laboratory.
Formulation of Quality Improvement Methodology for Risk Mitigation in Congenital Cardiac Catheterization.
Pediatr Cardiol
January 2025
The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
The C3PO collaborative, with a history of successful quality improvement (QI) initiatives, leveraged registry participants to develop a multi-center QI initiative to reduce adverse events (AEs) in congenital cardiac catheterization. A 32-person, interdisciplinary working group analyzed audited data for all congenital cardiac catheterization cases from 2014-2017. The primary outcome was the occurrence of any high-severity (level 3/4/5) AE.
View Article and Find Full Text PDFMachine learning prediction model for oral mucositis risk in head and neck radiotherapy: a preliminary study.
Support Care Cancer
January 2025
Oral Diagnosis Department, Faculdade de Odontolodia de Piracicaba, Universidade de Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Purpose: Oral mucositis (OM) reflects a complex interplay of several risk factors. Machine learning (ML) is a promising frontier in science, capable of processing dense information. This study aims to assess the performance of ML in predicting OM risk in patients undergoing head and neck radiotherapy.
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