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Bacteremic nosocomial pneumonia caused by Gram-negative bacilli: results from the nationwide ALARICO study in Italy.
Infection
December 2024
Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Italy.
Purpose: To describe the clinical characteristics and outcomes of patients with nosocomial pneumonia (NP) caused by carbapenem-resistant Gram-negative bacilli (CR-GNB) and to compare them to patients with NP caused by carbapenem-susceptible (CS)-GNB.
Methods: Prospective observational multicenter study including patients with bacteremic NP caused by GNB from the ALARICO Network (June 2018-January 2020). The primary outcome measure was 30-day mortality.
Risk factors for bacteremia in infants with urinary tract infection.
Pediatr Neonatol
October 2024
Department of Pediatrics, Pingtung Veterans General Hospital, Pingtung, Taiwan; Division of Pediatric Nephrology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address:
Background: Some infants with urinary tract infection (UTI) may exhibit concurrent bacteremia, potentially leading to septic shock or bacterial meningitis. Identifying risk factors for bacteremia in infants with UTI is crucial for prompt intervention to prevent subsequent adverse outcomes.
Methods: Between 2015 and 2021, a total of 632 infants with UTI aged ≤12 months were enrolled at Kaohsiung Veterans General Hospital (KSVGH), among whom 20 had concurrent bacteremia.
Diagnostic Potential of Serum Interleukin-6 in Predicting Bacteremia in Adult Patients with Sepsis: A Prospective Observational Study.
Indian J Crit Care Med
July 2024
Faculty of Biochemistry, Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: This study aimed to assess the potential of serum interleukin-6 (IL-6) as a diagnostic marker in predicting bacteremia and to determine its association with severity and outcome among sepsis patients.
Materials And Methods: A prospective observational study was conducted, comprising a cohort of 118 patients admitted to the ICU with suspected sepsis from January 2019 to April 2020.
Results: Among the 108 patients analyzed, 60 (55.
Case Report: Severe Community-Acquired Pneumonia in Réunion Island due to Acinetobacter baumannii.
Am J Trop Med Hyg
July 2024
Department of Intensive Care Medicine, Felix Guyon University Hospital, Saint-Denis, France.
Article Synopsis
- Acinetobacter baumannii (Ab) is a significant cause of severe community-acquired pneumonia (CAP) in tropical regions, particularly noted in a study from Réunion University Hospital, where eight cases were reviewed from 2014 to 2022.
- The majority of patients were middle-aged males with a history of smoking and chronic alcohol use, presenting during the rainy season and often experiencing septic shock and severe respiratory distress.
- The mortality rate was high at 62.5%, with all patients initially receiving inappropriate antibiotic treatment; however, Ab isolates were mostly susceptible to several key antibiotics.
Clinical effectiveness of cefiderocol for the treatment of bloodstream infections due to carbapenem-resistant Acinetobacter baumannii during the COVID-19 era: a single center, observational study.
Eur J Clin Microbiol Infect Dis
June 2024
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy.
Background: We assessed the clinical effectiveness of cefiderocol (CFDC) in comparison with colistin (COL) for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infections (BSI).
Materials/methods: Retrospective cohort study including adults with CRAB-BSI. Outcomes were mortality, clinical cure and adverse events during therapy.
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