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Iron Drives Eosinophil Differentiation in Allergic Airway Inflammation Through Mitochondrial Metabolic Adaptation.
Adv Healthc Mater
January 2025
Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
Eosinophils play a crucial role as effector cells in asthma pathogenesis, with their differentiation being tightly regulated by metabolic mechanisms. While the involvement of iron in various cellular processes is well known, its specific role in eosinophil differentiation has largely remained unexplored. This study demonstrates that iron levels are increased during the differentiation process from eosinophil progenitors to mature and activated eosinophils in the context of allergic airway inflammation.
View Article and Find Full Text PDFMicroencapsulated Escape Lysine with Tannin as an Adjuvant in Sheep Diets.
Vet Sci
January 2025
Graduate Program in Animal Science and Health, Federal University of Campina Grande, Patos 58708110, Brazil.
The use of escape protein, which is absorbed in the small intestine, can improve the production of ruminant animals because it meets their protein requirements better. This study hypothesized that wax lipid matrices are effective encapsulants for escape lysine in ruminants and tested tannin extract as an adjuvant. Forty intact male Santa Ines × Dorper sheep (~4 months old, BW 23 ± 1.
View Article and Find Full Text PDFInvestigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study.
Heliyon
January 2025
Department of Prosthodontia, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, India.
The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide contributing to a large number of mortalities. Though potentially curable they are mostly fatal due to late diagnosis and lack of accurate diagnostic markers. microRNA, micromanagers of gene expression have been associated to have distinct roles as oncogenes or tumour suppressors in several cancers including GI cancers.
View Article and Find Full Text PDFSystematic characterization of faecal sludge from various sources for its use as a solid fuel.
Biomass Convers Biorefin
September 2023
Department of Water Supply, Sanitation and Environmental Engineering, IHE Delft Institute for Water Education, Westvest 7, 2611 AX Delft, the Netherlands.
Faecal sludge (FS) is not extensively evaluated for its potential as a solid fuel mainly due to the general conception of its "highly variable characteristics" in relation to the wide range of on-site sanitation systems. An extensive and systematic FS characterization was therefore conducted on twenty-four samples collected directly from pit latrines, ventilated improved pit latrines (VIPs) and urine-diverting dehydrating toilets (UDDTs) at two depths to understand the impact on properties relevant for combustion. The higher heating value (HHV) for these samples lies between 13 to 22 MJ/kg DM (dry matter).
View Article and Find Full Text PDFInvolving national stakeholders in a systems approach to map drivers of childhood obesity and actions to prevent childhood obesity in Denmark: the Generation Healthy Kids Study.
Health Res Policy Syst
January 2025
Center for Clinical Research and Prevention, Health Promotion and Prevention, Frederiksberg Hospital, Frederiksberg, Denmark.
Background: Childhood obesity is a preventable global public health challenge, increasingly recognized as a complex problem, stemming from complex drivers. Obesity is characterized by multiple interdependencies and diverse influences at different societal levels. Tackling childhood obesity calls for a holistic approach that engages with complexity and recognizes that there is no single "magic bullet" intervention to prevent obesity.
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