AI Article Synopsis
- The study on mice with mutant T-cell antigen receptor genes shows that TCR-beta rearrangement is essential for the maturation of specific thymocytes (CD4-CD8- to CD4+CD8+) and their increased numbers.
- TCR-alpha does not play a significant role in this differentiation process.
- The formation of gamma delta T cells occurs independently of both TCR-alpha and TCR-beta.
Article Abstract
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.
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| http://dx.doi.org/10.1038/360225a0 | DOI Listing |
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