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Heliyon
January 2025
Jade University of Applied Sciences, Institute for Applied Photogrammetry and Geoinformatics, Ofener Str. 16, Oldenburg, 26129, Lower Saxony, Germany.
Though numerous studies acknowledge the critical role played by green spaces (GS) in bolstering sustainability in various dimensions, a majority of these investigations primarily center on the ecological aspect and urban environments. Due to the multifaceted benefits of GSs, different categories and expectations of these spaces can be identified across disciplines. Hence, no single method exists for evaluating the success of GSs in promoting sustainability due to the multifaceted benefits and variety of expectations.
View Article and Find Full Text PDFUnlabelled: Early phase dose-finding (EPDF) trials are key in the development of novel therapies, with their findings directly informing subsequent clinical development phases and providing valuable insights for reverse translation. Comprehensive and transparent reporting of these studies is critical for their accurate and critical interpretation, which may improve and expedite therapeutic development. However, quality of reporting of design characteristics and results from EPDF trials is often variable and incomplete.
View Article and Find Full Text PDFChem Eng J
July 2024
Program in Environmental and Polymer Engineering, Graduate School of INHA University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Korea.
Microplastics (MPs) have been detected in various environmental matrices, drinking water, and food, and their presence is an ecological and human health concern. Most research on MPs has focused solely on their detection and analysis. However, sample pretreatment methods are critical for accurate MP analysis and must be properly established.
View Article and Find Full Text PDFBMC Med Res Methodol
January 2025
Center of Orthopaedics and Traumatology, University Hospital Brandenburg/Havel, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany.
The purpose of this article is to design and introduce the SQUARE-IT approach to help scientists and clinicians in research to align important research problems with the objectives, the appropriate clinical research questions to be answered, and the research hypotheses to be investigated in medical and therapeutic specialties. Research ideas can be generated primarily through simple methods such as brainstorming and mind mapping. However, transforming ideas into a valid research question is not as easy as it may seem, as the mere presence of an idea does not guarantee that the researcher has already uncovered existing knowledge on a particular topic or identified the actual research problem.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, China.
The skeleton is highly innervated by numerous nerve fibers. These nerve fibers, in addition to transmitting information within the bone and mediating bone sensations, play a crucial role in regulating bone tissue formation and regeneration. Traditional bone tissue engineering (BTE) often fails to achieve satisfactory outcomes when dealing with large-scale bone defects, which is frequently related to the lack of effective reconstruction of the neurovascular network.
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