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| http://dx.doi.org/10.1172/JCI103748 | DOI Listing |
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Quercetin Supplementation Reduces Oxidative Stress in the Testes of Wistar Rats Fed a High-Fat Diet.
Am J Reprod Immunol
January 2025
Laboratory of Molecular Genetics and Experimentation in Animal Reproduction, University of Western São Paulo (Unoeste), Presidente Prudente, São Paulo, Brazil.
Problem: A high-fat diet (HFD) predisposes animals to glucose intolerance, dyslipidemia and testicular oxidative stress, and impairs sperm production in rats. Quercetin is a flavonoid with antioxidant, anti-inflammatory, and lipolytic actions and is a potential supplement to combat the oxidative stress caused by HFD and its harmful effects on reproduction. This study evaluated the effects of quercetin supplementation at doses of 10 and 20 mg/day on reproductive parameters and testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose.
View Article and Find Full Text PDFMultifaceted action of stem cell-derived extracellular vesicles for nonalcoholic steatohepatitis.
J Control Release
October 2023
Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Gangwon-do 25354, South Korea; Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do 25354, South Korea. Electronic address:
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with metabolic syndrome. Extracellular vesicles (EVs) are essential signaling mediators containing functional biomolecules. EVs are secreted from various cell types, and recent studies have shown that mesenchymal stem cell-derived EVs have therapeutic potential against immune and metabolic diseases.
View Article and Find Full Text PDFLipid Metabolism as a Target Site in Pest Control.
Adv Exp Med Biol
October 2024
Bayer AG, Crop Science Division, Monheim, Germany.
Lipid metabolism is essential to insect life as insects use lipids for their development, reproduction, flight, diapause, and a wide range of other functions. The central organ for insect lipid metabolism is the fat body, which is analogous to mammalian adipose tissue and liver, albeit less structured. Various other systems including the midgut, brain, and neural organs also contribute functionally to insect lipid metabolism.
View Article and Find Full Text PDFChromium and palmitic acid supplementation modulate adipose tissue insulin sensitivity in postpartum dairy cows.
J Dairy Sci
January 2025
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824. Electronic address:
Periparturient dairy cows exhibit intense lipolysis driven by reduced DMI, enhanced energy needs, and the loss of adipose tissue (AT) insulin sensitivity. Extended periods of low insulin sensitivity and negative energy balance induce lipolysis dysregulation, leading to increased disease susceptibility and poor lactation performance. Chromium (Cr) supplementation improves systemic insulin sensitivity, whereas palmitic acid (PA) increases energy availability for milk production.
View Article and Find Full Text PDFLabel-free quantitative proteomic profiling reveals differential plasma protein expression in patients with obesity after treatment with liraglutide.
Front Mol Biosci
September 2024
Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- The study explored the effects of the GLP-1 receptor agonist liraglutide on plasma protein profiles in patients with obesity, finding significant changes in weight, BMI, and HbA1c after three months of treatment.
- A total of 151 proteins showed significant dysregulation, with 31 being upregulated and 120 downregulated post-treatment, highlighting potential biomarkers like Cystatin-B and multimerin-2.
- Pathway analysis revealed major signaling pathways involved, particularly MAPK, AKT, and PKc, which play a crucial role in cell communication and could inform future obesity treatments.
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