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Improving medicinal plant cultivation through in-depth understanding of environmental, physiological, metabolic, and genetic constraints.
J Exp Bot
January 2025
UCD School of Biology and Environmental Science and Earth Institute, University College Dublin, Belfield, Dublin, Ireland.
Research progress of paclitaxel nanodrug delivery system in the treatment of triple-negative breast cancer.
Mater Today Bio
December 2024
State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by the loss or low expression of estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2) and progesterone receptor (PR). Due to the lack of clear therapeutic targets, paclitaxel (PTX) is often used as a first-line standard chemotherapy drug for the treatment of high-risk and locally advanced TNBC. PTX is a diterpenoid alkaloid extracted and purified from Taxus plants, functioning as an anticancer agent by inducing and promoting tubulin polymerization, inhibiting spindle formation in cancer cells, and preventing mitosis.
View Article and Find Full Text PDFPost-genomic illumination of paclitaxel biosynthesis.
Nat Plants
December 2024
Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Article Synopsis
- * Currently, paclitaxel is produced through a semi-synthesis process, using a compound called baccatin III extracted from Taxus plants, although many biosynthesis intermediates remain unknown.
- * Recent genomic studies have identified key genes for baccatin III and paclitaxel biosynthesis, which could lead to advancements in understanding the full biosynthetic pathway and improving industrial production through synthetic biology, despite ongoing significant challenges.
[Severe intoxication after yew (Taxus) ingestion-case report and literature review].
Med Klin Intensivmed Notfmed
October 2024
Asklepios Klinik Altona, Abteilung für Kardiologie und internistische Intensivmedizin, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
Background: Severe yew (Taxus) intoxication is a rare condition that can lead to life-threatening cardiac arrhythmia. The survival of patients requires highly specialized emergency and intensive care treatment.
Objectives: Systematic overview of the clinical picture and important treatment options.
Microscopic distribution of taxanes in freeze-fixed stems of .
Front Chem
August 2024
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Introduction: species contain the anticancer alkaloid paclitaxel, as well as other taxanes similar in structure and potentially in effect to paclitaxel. Tissue-specific distribution patterns and seasonal variations of taxanes in some species have been reported; however, it is still under-presented for the taxanes in .
Methods: The radial distributions of eight taxanes in the transverse surface of freeze-fixed stems from the late summer and the spring seasons were investigated by cryo-time-of-flight secondary ion mass spectrometry and scanning electron microscopy (cryo-TOF-SIMS/SEM) visualization and liquid chromatography-mass spectrometry (LC-MS) quantitative analysis.
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