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Silent witnesses: unveiling the epidemic of femicides in North-west Tshwane, South Africa - a decade of analysis.
BMC Public Health
January 2025
Sefako Makgatho University, Ground Floor, Clin Path Building, Room No. 37. Garankuwa, Pretoria, South Africa.
Background: Femicides, defined as the gender-based killing of women, are a pressing public health issue worldwide, with South Africa experiencing some of the highest rates globally. This study focuses on the North-west region of Tshwane, particularly the Garankuwa area, aiming to address gaps in understanding the epidemiology, demographics, circumstances, and pathology associated with femicides. The Garankuwa mortuary serves as the primary site for this investigation, providing a detailed analysis over a ten-year period, shedding light on contributing risk factors in the context of systemic gender inequality.
View Article and Find Full Text PDFThe study of mechanical properties and fracture evolution of coal-rock masses under hard roof-soft floor conditions.
Sci Rep
January 2025
School of Mechanical and Engineering, Liaoning Technical University, Fuxin, 123000, China.
As the depth of coal mining in China continues to increase, the fracturing of coal rock masses has an increasingly complex impact on the surrounding rock roadways. The majority of the mine's roadways run through coal rock masses with hard roofs and soft bottoms, which typically exhibit complex dynamic behaviour. To further research the mechanical behaviour and fracture evolution of coal rock masses under hard-roof and soft-floor conditions, the study is based on the majority of working faces in a mine, which have hard roofs and soft floors.
View Article and Find Full Text PDFCaML: Chemistry-informed machine learning explains mutual changes between protein conformations and calcium ions in calcium-binding proteins using structural and topological features.
Protein Sci
February 2025
Department of Physics, University of Washington, Seattle, Washington, USA.
Proteins' flexibility is a feature in communicating changes in cell signaling instigated by binding with secondary messengers, such as calcium ions, associated with the coordination of muscle contraction, neurotransmitter release, and gene expression. When binding with the disordered parts of a protein, calcium ions must balance their charge states with the shape of calcium-binding proteins and their versatile pool of partners depending on the circumstances they transmit. Accurately determining the ionic charges of those ions is essential for understanding their role in such processes.
View Article and Find Full Text PDFFrom Guidelines to Action: Tackling Risk Factors for Surgical Site Infections.
Antibiotics (Basel)
January 2025
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Surgical site infections are a serious public health concern, representing a significant burden on healthcare systems and society. Their occurrence is influenced by several factors, including patient demographics, healthcare facilities and the specific circumstances surrounding surgery. The use of prophylactic antibiotics in this context carries both potential benefits and risks.
View Article and Find Full Text PDFInvestigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers.
Biomedicines
January 2025
School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar 751024, Odisha, India.
: Cancer is caused by disruptions in the homeostatic state of normal cells, which results in dysregulation of the cell cycle, and uncontrolled growth and proliferation in affected cells to form tumors. Successful development of tumorous cells proceeds through the activation of pathways promoting cell development and functionality, as well as the suppression of immune signaling pathways; thereby providing these cells with proliferative advantages, which subsequently metastasize into surrounding tissues. These effects are primarily caused by the upregulation of oncogenes, of which SPP1 (secreted phosphoprotein 1), a non-collagenous bone matrix protein, is one of the most well-known.
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