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Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function.
Sci Adv
March 2025
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Preterm birth is detrimental to the well-being of both the mother and the newborn. During normal gestation, the myometrium is maintained in a quiescent state by progesterone. As a steroid hormone, progesterone is thought to modify uterine and placental morphology by altering gene expression, but another direct mode of action has long been suspected.
View Article and Find Full Text PDFOsmolarity regulates egg-laying behavior via parallel chemosensory and biophysical mechanisms.
bioRxiv
December 2024
Department of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146.
Animals alter their behavior in response to changes in the environment. Upon encountering hyperosmotic conditions, the nematode worm initiates avoidance and cessation of egg-laying behavior. While the sensory pathway for osmotic avoidance is well-understood, less is known about how egg laying is inhibited.
View Article and Find Full Text PDFNovel screening approach for stem cell selective inhibitors and their possible translational therapeutic potential for endometriosis.
Reprod Biol
March 2025
Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Endometriosis is an estrogen-dependent benign disease characterized by growth of the endometrial tissue outside the uterine wall. Several reports suggest the possibility of the pathogenesis and recurrence of endometriosis being related to functions of stem/progenitor cells of the endometrium. The drawback of the widely used method of using Hoechst 33342, a fluorescent dye, to collect stem cell-like populations, is the requirement of an ultraviolet (UV) excitation source not commonly provided on standard flow cytometers.
View Article and Find Full Text PDFA computationally efficient anisotropic electrophysiological multiscale uterus model: From cell to organ and myometrium to abdominal surface.
Comput Methods Programs Biomed
December 2024
Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València (Ci2B), Valencia 46022, Spain; BJUT-UPV Joint Research Laboratory in Biomedical Engineering, Beijing, China. Electronic address:
Background And Objective: Preterm labor is a global problem affecting the health of newborns. Despite numerous studies reporting electrophysiological changes throughout pregnancy, the underlying mechanism that triggers labor remains unclear. Electrophysiological modeling can provide additional information to better understand the physiological transition from pregnancy to labor.
View Article and Find Full Text PDFAn update on pacemaking in the myometrium.
J Physiol
July 2024
Biosciences Institute, International Centre for Life, Newcastle University, Newcastle, UK.
Timely and efficient contractions of the smooth muscle of the uterus - the myometrium - are crucial to a successful pregnancy outcome. These episodic contractions are regulated by spontaneous action potentials changing cell and tissue electrical excitability. In this short review we will document and discuss current knowledge of these processes.
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