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Detection of Sialic Acid to Differentiate Cervical Cancer Cell Lines Using a Lectin Biosensor.
Biosensors (Basel)
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Laboratorio de Bionanotecnología, Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional (IPN-CIBA), Tepetitla 90700, Mexico.
Pap smear screening is a widespread technique used to detect premalignant lesions of cervical cancer (CC); however, it lacks sensitivity, leading to identifying biomarkers that improve early diagnosis sensitivity. A characteristic of cancer is the aberrant sialylation that involves the abnormal expression of α2,6 sialic acid, a specific carbohydrate linked to glycoproteins and glycolipids on the cell surface, which has been reported in premalignant CC lesions. This work aimed to develop a method to differentiate CC cell lines and primary fibroblasts using a novel lectin-based biosensor to detect α2,6 sialic acid based on attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and chemometric.
View Article and Find Full Text PDFDevelopmental and reproductive safety of Advax-CpG55.2™ adjuvanted COVID-19 and influenza vaccines in mice.
Vaccine
September 2023
Vaxine Pty Ltd., Bedford Park, Adelaide, SA 5042, Australia. Electronic address:
SpikoGen® is a recombinant spike protein vaccine against COVID-19 that obtained marketing authorization in the Middle East on October 6, 2021, becoming the first adjuvanted protein-based COVID-19 vaccine of its type to achieve approval. SpikoGen® vaccine utilizes a unique adjuvant Advax-CpG55.2, which comprises delta inulin and CpG55.
View Article and Find Full Text PDFMolecular Evolution of Human Parainfluenza Virus Type 2 Based on Hemagglutinin-Neuraminidase Gene.
Microbiol Spectr
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National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
To understand the molecular evolution of human parainfluenza virus type 2 (HPIV2), 21 Hemagglutinin-Neuraminidase (HN) gene sequences covering seven Chinese provinces in 2011 and 2017 to 2021 were combined with 90 published HN sequences worldwide for phylogenetic analysis. The result showed that global HPIV2 could be classified into two distinct clusters (I and II), five lineages (IA to IIE), and four sublineages (IB1 and 2, and IIE1 and 2). The minimum genetic distances between different clusters and lineages were 0.
View Article and Find Full Text PDFPreformulation Characterization of Griffithsin, a Biopharmaceutical Candidate for HIV Prevention.
AAPS PharmSciTech
February 2021
Magee-Womens Research Institute, 204 Craft Avenue, Room B509, Pittsburgh, Pennsylvania, 15213, USA.
Griffithsin (GRFT) has shown potent anti-HIV activity, and it is being developed as a drug candidate for HIV prevention. Successful implementation requires thorough understanding of its preformulation characterization. In this work, preformulation assessments were conducted to characterize GRFT and identify its degradation pathways under selected conditions of temperature, light, pH, shear, ionic strength, and oxidation.
View Article and Find Full Text PDFEfficacy of silk fibroin biomaterial vehicle for in vivo mucosal delivery of Griffithsin and protection against HIV and SHIV infection ex vivo.
J Int AIDS Soc
October 2020
Department of Medical Microbiology & Immunology, School of Medicine, University of California Davis, Davis, CA, USA.
Article Synopsis
- * Researchers formulated an HIV inhibitor called Griffithsin (Grft) within the SF platform and conducted tests using non-human primates and human tissue models to assess its safety and efficacy.
- * Results showed that the SF-Grft system effectively released the HIV inhibitor and provided protection against HIV without causing inflammation or disrupting local microbiota in both vaginal and rectal tissues.
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