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Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats.
BMC Genomics
July 2024
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, P. R. China.
Background: Breeding polled goats is a welfare-friendly approach for horn removal in comparison to invasive methods. To gain a comprehensive understanding of the genetic basis underlying polledness in goats, we conducted whole-genome sequencing of 106 Xinong Saanen dairy goats, including 33 horned individuals, 70 polled individuals, and 3 polled intersexuality syndrome (PIS) individuals.
Methods: The present study employed a genome-wide association study (GWAS) and linkage disequilibrium (LD) analysis to precisely map the genetic locus underlying the polled phenotype in goats.
Testosterone therapy in females is not associated with increased cardiovascular or breast cancer risk: a claims database analysis.
J Sex Med
April 2024
The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, United States.
Background: Testosterone therapy (TTh) has been shown to improve libido in women with sexual dysfunction, but its utilization has been limited due to concern for cardiovascular events and past studies reporting highly variable results.
Aim: To assess the association of TTh in women with major adverse cardiac events (MACEs), including heart attack, stroke, or death, using a large database.
Methods: The TriNetX Diamond Network was queried from 2009 to 2022.
A prospective study on disorders of sex development in Duhok city, Kurdistan region, Iraq: Genetic, etiology and clinical presentation.
Cell Mol Biol (Noisy-le-grand)
December 2023
University of Duhok, College of Medicine, KRO, Duhok, Kurdistan, Iraq.
Disorders of Sexual Development (DSD) encompass all types of intersex cases and have been reported globally. However, in Iraq, studies related to DSD are scanty. The current single-center prospective study was carried out to find out the frequency, genetic and clinical presentation of different types of DSDs in the sample population of Duhok, Iraq.
View Article and Find Full Text PDFSex-specific differences in ectopic fat and metabolic characteristics of paediatric nonalcoholic fatty liver disease.
Int J Obes (Lond)
April 2024
Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea.
Background/objectives: Sex-specific differences in obesity-related metabolic characteristics of non-alcoholic fatty liver disease (NAFLD) have rarely been explored, particularly in children with biopsy-verified NAFLD. The influence of sex hormones on ectopic fat disposition may cause inter-sex differences in various metabolic factors. This study aimed to assess the sex-based differences in ectopic fat and metabolic characteristics in children with NAFLD.
View Article and Find Full Text PDFBackground: Understanding the attitudes of medical students towards individuals from the lesbian, gay, bisexual, transgender, queer, questioning, intersex and asexual (LGBTQIA+) community is a prerequisite for informing competencies-based medical education (CBME) guidelines to make them LGBTQIA+ inclusive. The present study was conducted to assess the attitudes of medical undergraduate students from Indian medical colleges towards the LGBTQIA+ community.
Methods: An online cross-sectional survey was conducted in medical undergraduate students across India, which measured the opinions, beliefs, and acceptance of LGBTQIA+ people using a structured questionnaire uploaded on Google Forms.
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