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Return of individual research results to participants with and at risk for Parkinson's disease.
J Clin Transl Sci
October 2024
Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA.
In a prospective, remote natural history study of 277 individuals with (60) and genetically at risk for (217) Parkinson's disease (PD), we examined interest in the return of individual research results (IRRs) and compared characteristics of those who opted for versus against the return of IRRs. Most ( = 180, 65%) requested sharing of IRRs with either a primary care provider, neurologist, or themselves. Among individuals without PD, those who requested sharing of IRRs with a clinician reported more motor symptoms than those who did not request any sharing (mean (SD) 2.
View Article and Find Full Text PDFEponyms that honor Jewish dermatologists: A celebration and a remembrance, Part three: Jewish physicians who practiced during the Holocaust and in its aftermath.
Clin Dermatol
June 2024
Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Part III of this contribution continues to celebrate the many contributions that Jewish physicians have made to advance the specialty of dermatology, as reflected by eponyms that honor their names. Part I covered the years before 1933, a highly productive period of creativity by Jewish dermatologists, especially in Germany and Austria. The lives of 17 Jewish physicians and their eponyms were described in Part I.
View Article and Find Full Text PDFAdvancements in diagnostic and interventional radiology for stroke treatment: the path from trial to bedside through the pre-MR CLEAN, MR CLEAN, and MR CLEAN II eras.
Insights Imaging
January 2024
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Article Synopsis
- * The MR CLEAN II trials further established the importance of radiologists in both diagnosing and treating strokes, finding that aspirin and heparin during endovascular treatment increase the risk of complications, while also confirming the benefits of treatment up to 24 hours after stroke onset in certain conditions.
- * These trials have reshaped clinical guidelines and practices, underscoring the collaborative efforts among radiologists, interventionalists, and neurologists, contributing to better patient care and effective stroke management strategies.
Bernard Bornstein (1900-1977): His life and contribution to Polish and Israeli neurology.
J Med Biogr
August 2024
Katedra i Klinika Psychiatrii, Warszawski Uniwersytet Medyczny Katedra i Klinika Psychiatryczna, Warszawa, Poland.
Bernard Bornstein (1900-1975) was one of a few Polish-Jewish neurologists who escaped the tragic fate of Jews in Nazi-occupied Poland. Educated at the University of Vienna and practicing until the war in Cracow, Bornstein in his scientific work dealt comprehensively with various neurological topics, bringing to Israeli medicine the best of pre-War European neurological diagnostics and combining them with the latest achievements of genetics. He was a teacher of many prominent Israeli neurologists.
View Article and Find Full Text PDFAssociation of Brain Atrophy With Functional Outcome and Recovery Trajectories After Thrombectomy: Post Hoc Analysis of the ESCAPE-NA1 Trial.
Neurology
October 2023
From the Maastricht University Medical Center+ (MUMC+) (F. Benali); Calgary Stroke Program (F. Benali, J.F., T.J., F. Bala, N.S., J.M.O., M.D.H., M.G., A.G.), Department of Clinical Neurosciences, University of Calgary Cumming School of Medicine; and NoNO (M.T.), Toronto, ON, Canada.
Background And Objectives: Brain frailty may impair the ability of acute stroke patients to cope with the injury, irrespective of their chronologic age, resulting in impaired recovery. We aim to investigate the impact of brain atrophy on functional outcome assessed at different time points after endovascular thrombectomy (EVT).
Methods: In this retrospective post hoc analysis of the ESCAPE-NA1 trial, we analyzed CT imaging data for cortical atrophy by using the GCA scale, including region-specific scales, and subcortical atrophy by using the intercaudate distance to inner table width (CC/IT) ratio.
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