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Retinal and Choroidal Circulation Impairments in Fanconi Anemia.
Am J Ophthalmol
January 2025
Hacettepe University School of Medicine, Department of Ophthalmology, Ankara, Turkey.
Objective: To evaluate the effects of Fanconi anemia (FA) on retinal and choroidal microvasculature using Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA).
Design: Cohort study with age-matched controls.
Subjects And Participants: This study included 11 eyes from 11 patients diagnosed with FA and 12 eyes from 12 age-matched healthy controls.
The secreted protease ADAMTS18 links early isoform transformation and maturation of glomerular basement membrane macromolecules to the integrity of the glomerular filtration barrier.
Biochem Biophys Res Commun
January 2025
Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
The glomerular filtration barrier (GFB) has a unique spatial structure, including porous capillary endothelial cells, glomerular basal membrane (GBM) and highly specialized podocytes. This special structure is essential for the hemofiltration process of nephrons. GBM is the central meshwork structure of GFB formed by the assembly and fusion of various extracellular matrix (ECM) macromolecules, such as laminins and collagens, which undergo isoform transformation and maturation that may require precise regulation by metalloproteinases.
View Article and Find Full Text PDFClinicopathological analysis of anti-VEGF drug-associated renal thrombotic microangiopathy: A case series and review of the literature.
Pathol Res Pract
January 2025
Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China.
Anti-vascular endothelial growth factor-associated thrombotic microangiopathy (aVEGF-TMA) was recently discovered in patients with malignant tumors. Four aVEGF-TMA patients diagnosed by renal biopsy between 2018 and 2022 were identified, and all were females aged 30-62 years (mean age, 47 years). Two patients with malignant gastrointestinal stromal tumors who received sunitinib were analyzed.
View Article and Find Full Text PDFIslet Autoantibody Screening Throughout Australia Using In-Home Blood Spot Sampling: 2-Year Outcomes of Type1Screen.
Diabetes Care
January 2025
Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Objective: Type1Screen offers islet autoantibody testing to Australians with a family history of type 1 diabetes (T1D) with the dual aims of preventing diabetic ketoacidosis (DKA) and enabling use of disease-modifying therapy. We describe screening and monitoring outcomes 2 years after implementing in-home capillary blood spot sampling.
Research Design And Methods: Data from 2,064 participants who registered between July 2022 and June 2024 were analyzed: 1,507 and 557 chose blood spot and venipuncture screening respectively.
Whispering-gallery-mode (WGM) microresonators are typically studied for surface (bio)chemical sensing, mainly relying on small refractive index changes occurring within a nanometer range from their walls surface. This high sensitivity, reaching up to 10 refractive index unit (RIU, ∼2.5 nm/RIU and measured at a femtometer resolution) leads to broad ranges of applications, especially for biosensing purposes through the monitoring of molecular binding events.
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