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Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol.
Biol Psychol
December 2013
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Osaka, Japan. Electronic address:
In this study, we examined the relationship between fatigue and plasma concentrations of antioxidants and lipid peroxidation products. Fourteen healthy volunteers performed overnight desk work for 18h then took a nap for 4h. Participants answered questionnaires of subjective symptoms of fatigue (QSSF) and completed a self-assessment of fatigue using a visual analog scale (VAS).
View Article and Find Full Text PDFOccurrence, biosynthesis and function of isoprenoid quinones.
Biochim Biophys Acta
September 2010
Department of Plant Physiology and Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Isoprenoid quinones are one of the most important groups of compounds occurring in membranes of living organisms. These compounds are composed of a hydrophilic head group and an apolar isoprenoid side chain, giving the molecules a lipid-soluble character. Isoprenoid quinones function mainly as electron and proton carriers in photosynthetic and respiratory electron transport chains and these compounds show also additional functions, such as antioxidant function.
View Article and Find Full Text PDFDistribution of tocopheryl quinone in mitochondrial membranes and interference with ubiquinone-mediated electron transfer.
Biochem Pharmacol
May 2006
Research Institute for Biochemical Pharmacology and Molecular Toxicology, University of Veterinary Medicine Vienna, Austria.
Alpha-tocopherol (Toc) is an efficient lipophilic antioxidant present in all mammalian lipid membranes. This chromanol is metabolized by two different pathways: excessive dietary Toc is degraded in the liver by side chain oxidation, and Toc acting as antioxidant is partially degraded to alpha-tocopheryl quinone (TQ). The latter process and the similarity between TQ and ubiquinone (UQ) prompted us to study the distribution of TQ in rat liver mitochondrial membranes and the interference of TQ with the activity of mitochondrial and microsomal redox enzymes interacting with UQ.
View Article and Find Full Text PDFOxidized vitamin E and ubiquinone: competition for binding sites of the mitochondrial cytochrome bc1 complex?
Ann N Y Acad Sci
December 2004
Research Institute of Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.
Redox-interaction of alpha-tocopheryl quinone with isolated mitochondrial cytochrome bc1 complex.
Biochem Pharmacol
July 2004
Research Institute for Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinärpl. 1, A-1210 Vienna, Austria.
The homogenous distribution of vitamin E in lipid membranes is a prerequisite for its universal function as lipophilic antioxidant. Its antioxidant activity leads to the irreversible formation of alpha-tocopheryl quinone (TQ) in those membranes. Very little is known about the interference of TQ with redox-cycling enzymes normally interacting with ubiquinone (UQ), which exerts important bioenergetic functions in the mitochondrial respiratory chain.
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