[Hyperbaric oxygenation and antianginal agents: effects on blood levels of malondialdehyde and activities of antioxidative enzymes in patients with ischemic heart disease].

The time course of serum levels of malonic dialdehyde and red blood cell activity of antioxidative enzymes, such as superoxide dismutase and glutathione peroxidase, was assessed from the outcomes of hyperbaric oxygenation combined with antianginal therapy in 38 patients with functional classes II-III stable angina on effort without clinical manifestations of circulatory failure. Hyperbaric oxygenation involved 10-12 sessions at 1.5 ata during 40 min each. The antianginal agents (long-acting nitrates, beta-adrenoblockers, nifedipine) were given in median therapeutical doses. The control group included 26 patients who had hyperbaric oxygenation in the same fashion without taking antianginal drugs. The criteria for beneficial therapy were a reduction in the number of anginal episodes and the nitroglycerin tablets used, an increase in exercise tolerance, as evidenced by repeated bicycle ergometric test. The positive clinical effect of a hyperbaric oxygenation course was shown to be accompanied by higher activity of superoxide dismutase in the red blood cells. The use of nifedipine in the multimodality anginal therapy prevents the hyperbaric oxygenation-induced increase in serum malonic dialdehyde levels.