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The synergistic effect between phages and Ceftolozane/Tazobactam in endotracheal tube biofilm.

Emerg Microbes Infect

December 2024

Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS, Barcelona, Spain.

Although an increased effectiveness has been suggested when phages and antibiotics are combined, this approach has not been tested against a mature biofilm on an endotracheal tube (ETT) surface. This study evaluated the effect of short- and long-term combined phage-antibiotic therapy in a control of a mature biofilm on an ETT surface. strains, including susceptible and resistant clinical samples, were used to develop the ETT biofilm.

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Background: Klebsiella spp. can colonize the intestine of preterm neonates, and over-growth has been associated with necrotizing enterocolitis, hospital-acquired infections, and late-onset sepsis. This could lead us to suggest that the clinical pertinence of intestinal colonization with ESBL in preterm neonates appears to be important.

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Idiopathic nonhistaminergic acquired angioedema in a patient with coronavirus disease 2019.

Ann Allergy Asthma Immunol

November 2020

Section of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.

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The primary objective of this randomized controlled challenge study was to investigate the effect of ampicillin on ultrasonographic (US) lung consolidation after experimental challenge with Pasteurella multocida in preweaned dairy calves. The secondary objectives were to determine whether ampicillin affected respiratory score, gross consolidation, or the detection of P. multocida in lung tissue at postmortem exam (PME).

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