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Targeting KAT7 inhibits the progression of colorectal cancer.
Theranostics
January 2025
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Epigenetic modifications play a significant role in the progression of CRC. KAT7, a histone acetyltransferase, has an unclear role in CRC.
View Article and Find Full Text PDFStrategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration.
Int J Nanomedicine
January 2025
Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.
Poor aqueous solubility and bioavailability limit the translation of new drug candidates into clinical applications. Nanocrystal formulations offer a promising approach for improving the dissolution rate and saturation solubility. These formulations are applicable for various routes of administration, with each presenting unique opportunities and challenges posed by the physiological barriers.
View Article and Find Full Text PDFProduction of free fatty acids by enzymatic hydrolysis of residual frying oil using non-commercial lipases from Aspergillus niger.
An Acad Bras Cienc
January 2025
Universidade Federal de Sergipe, Departamento de Engenharia Química - DEQ, Laboratório de Laboratório de Biotecnologia Ambiental (LABAM), Campus São Cristóvão, Rodovia Marechal Rondon, s/n, Rosa Elze, 49100-000 São Cristóvão, SE, Brazil.
Lipases are enzymes that have an important role in the industry for their wide use, giving rise to a great interest in industrial bioprocesses due to their versatility. One of the applications is the enzymatic hydrolysis of waste oils. This work consists of evaluating the production of lipases using several concentrations of residual frying oil (RFO) and different pHs, through ANOVA analysis.
View Article and Find Full Text PDFChanges in enzymatic activity and oxidative stress in honeybees kept in the apiary and laboratory conditions during the course of nosemosis.
PLoS One
January 2025
Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland.
The aim of this study was to investigate the changes in the level of oxidative stress and lysozyme-like and phenoloxidase (PO) activity under the influence of nosemosis. Honeybees were kept in natural (apiary) and artificial (laboratory) conditions. In this study, it was shown for the first time that honeybees kept in apiaries have higher levels and activity of the studied parameters than honeybees kept in the laboratory.
View Article and Find Full Text PDFChemical and Enzymatic Mechanosynthesis of Organocatalytic Peptide Materials Based on Proline and Phenylalanine.
ChemSusChem
January 2025
Universidad de Antioquia Facultad de Ciencias Exactas y Naturales, Instituto de Química, Calle 70 No 52-21, Medellín, NA, Medellín, COLOMBIA.
In recent years, mechanosynthesis of peptides through either chemical or enzymatic routes has been accomplished. In part, this advancement has been driven due to the organocatalytic properties of peptide-based biomaterials. In this work, we report the merging of chemical and enzymatic protocols under mechanochemical conditions to synthesize peptide materials based on L-proline and L-phenylalanine.
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