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Spectrum-effect relationship study between ultra-high-performance liquid chromatography fingerprints and anti-hepatoma effect in vitro of Cnidii Fructus.
Biomed Chromatogr
May 2024
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Cnidii Fructus, derived from the dried ripe fruit of Cnidium monnieri (L.) Cuss, has the effect of warming kidneys and invigorating Yang. This study established the spectrum-effect relationships between ultra-high-performance liquid chromatography (UHPLC) fingerprints and the antitumor activities of Cnidii Fructus on human hepatocellular carcinoma (HepG2) cells.
View Article and Find Full Text PDFMetabolic activation and cytotoxicity of metaxalone mediated by cytochrome P450 enzymes and sulfotransferases.
Chem Biol Interact
September 2023
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, 550025, PR China. Electronic address:
Metaxalone (MTX) is a central nervous system (CNS) depressant used for the treatment of acute skeletal muscle pain. Several cases of fatal overdose deaths in the clinical use of MTX, along with the presence of ischemic hepatitis in deceased patients, have been documented. The present study aimed to investigate the metabolic activation of MTX and to define the possible correlation between the metabolic activation and cytotoxicity of MTX.
View Article and Find Full Text PDF8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice.
Arch Biochem Biophys
June 2023
New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:
Article Synopsis
- This study explored how 8-methoxypsoralen (8-MOP) impacts liver damage caused by acetaminophen (APAP) in mice, revealing that 8-MOP reduces liver injury and inflammation indicators.
- Treatment with varying doses of 8-MOP showed a dose-dependent reduction in hepatotoxicity without affecting the liver negatively at the highest dose.
- The research indicates that 8-MOP works by inhibiting the Cyp2e1 enzyme, which decreases the formation of a toxic metabolite from APAP, thus providing a protective effect against liver damage.
Synthesis and biological evaluation of coumarin derivatives as selective CYP2A6 inhibitors.
Bioorg Med Chem Lett
April 2023
School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, Hokkaido 061-0293, Japan.
Cytochrome P450 2A6 (CYP2A6) inhibitors are expected to be suitable as smoking cessation aids and for cancer prevention. Because the typical coumarin-based CYP2A6 inhibitor methoxsalen also inhibits CYP3A4, unintended drug-drug interactions are still a concern. Therefore, the development of selective CYP2A6 inhibitors is desirable.
View Article and Find Full Text PDFExploration of the Components and Pharmacological Mechanisms of Keyin Pill-Induced Liver Injury Based on Network Pharmacology.
Evid Based Complement Alternat Med
December 2022
Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110840, China.
Background: Keyin pill (KP), a patented medicine in China, is used to treat psoriasis. However, KP has been reported to have liver toxicity, but its toxic substance basis and underlying mechanisms remain unclear. Therefore, this study aimed to explore the pharmacological mechanisms and components of KP-induced liver injury through animal experiments, UPLC-QTOF/MS combined with network pharmacology.
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