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| http://dx.doi.org/10.1136/bjo.42.7.441 | DOI Listing |
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RNA-binding proteins (RBPs) are critical regulators of mRNAs controlling all processes such as RNA transcription, transport, localization, translation, mRNA:ncRNA interactions, and decay. Cellular differentiation is driven by tissue-specific and/or tissue-preferred expression of proteins needed for the optimal function of mature cells, tissues and organs. Lens fiber cell differentiation is marked by high levels of expression of crystallin genes encoding critical proteins for lens transparency and light refraction.
View Article and Find Full Text PDFProgressive Keratoconus Treatment with Transepithelial Two-Step Phototherapeutic Keratectomy Combined with Corneal Crosslinking (CXL): Clinical Outcomes and Postoperative Management Including Potential Complications of the Modified Athens Protocol Designed for US-Approved Excimer Laser Specifications.
J Clin Med
November 2024
Ophthalmology Department, LaserVision Ambulatory Eye Surgery Unit, 11521 Athens, Greece.
To report a novel application within the USA of excimer ablation for the normalization of central corneal refractive irregularity, combined with higher fluence CXL in the effective management and visual rehabilitation of progressive keratoconus. 17 consecutive cases with progressive keratoconus were treated with corneal surface excimer laser ablation normalization using topography-guided (Contura) myopic ablation for customized corneal re-shaping with a 6 mm optical zone. The epithelial removal was accounted for by adding a -2.
View Article and Find Full Text PDFMetabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs.
Invest Ophthalmol Vis Sci
November 2024
Shanghai Institute of Infectious Disease and Biosecurity, Zhongshan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- Myopia in guinea pigs was induced using special lenses, and researchers investigated the metabolic changes in the sclera, focusing particularly on amino acid levels.
- Metabolomic analyses revealed significant alterations in metabolic pathways linked to myopia, highlighting reductions in specific amino acids in the affected sclera.
- Supplementing with glycine was found to counteract some effects of myopia, increasing collagen levels, inhibiting eye elongation, and reversing changes in certain proteins associated with this condition.
Association between central corneal thickness and systemic lupus erythematosus: a cross-sectional study protocol.
Front Med (Lausanne)
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Department of Clinical Medicine, School of Medicine, Miguel Hernández de Elche University, San Juan de Alicante, Spain.
Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple systems and classified under connective tissue disorders. Ocular involvement occurs in up to 30% of SLE cases, with the cornea being particularly susceptible to thinning due to immune-complex deposits and its predominantly type I collagen composition. This corneal thinning is clinically significant in glaucoma, where patients with reduced central corneal thickness (CCT) may have up to a threefold increased risk of developing glaucoma, as well as in refractive surgery.
View Article and Find Full Text PDFImpact of Genetic and Environmental Factors on Peripheral Refraction.
Transl Vis Sci Technol
October 2024
Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain.
Article Synopsis
- The study investigates how genetics and the environment affect refractive errors in both monozygotic (MZ) and dizygotic (DZ) twins by examining multiple eye measurements.
- The results show that MZ twins exhibit higher genetic influence in refractive errors compared to DZ twins, particularly for midperipheral defocus, indicating a significant role of genetics in peripheral vision.
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