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Identification and mechanism analysis of biomarkers related to butyrate metabolism in COVID-19 patients.
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
Test-Retest Reliability of Mismatch Negativity and Late Discriminative Negativity Response in Children With Listening Difficulties.
Eur J Neurosci
March 2025
School of Psychology, University of Auckland, Auckland, New Zealand.
The aim of the study was to determine the test-retest reliability of MMN and LDN recorded to simple speech contrasts in children with listening difficulties. MMN and LDN responses were recorded from Fz and Cz electrodes for a /da/-/ga/ contrast twice within a 10-day period. To extract MMN and LDN, auditory-evoked responses to /ga/ stimuli presented alone were subtracted from the responses to /ga/ presented within an oddball sequence.
View Article and Find Full Text PDFAdrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.
J Cell Mol Med
March 2025
Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses. However, the efficacy and underlying mechanisms of these treatments in BTC are still largely unexplored.
View Article and Find Full Text PDFRegulating the Crystallization and Morphology of PbI Precursor Films for the Growth of High-Quality Perovskite Films via Vapor-Solid Reaction.
ACS Appl Mater Interfaces
March 2025
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.
Developing vapor-solid reaction methods to prepare organic-inorganic hybrid perovskite thin films is highly compatible with processes in crystalline silicon solar cells and the thin-film photovoltaic industries, facilitating rapid industrialization. In the vapor-solid reaction, the crystallization quality of perovskite thin films is widely influenced by the crystallinity and microstructure of lead iodide (PbI) precursor films. During the thermal evaporation process of preparing the PbI precursor films, we observed that PbI tends to develop a disordered surface morphology and exhibits high crystallinity, which significantly hinders the uniform diffusion of the organic amine salt vapor during the subsequent vapor-solid reaction.
View Article and Find Full Text PDFEarly-pregnancy per- and polyfluoroalkyl substances and maternal post-pregnancy weight trajectory.
Obesity (Silver Spring)
March 2025
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Objective: The objective of this study was to evaluate associations of early-pregnancy plasma per- and polyfluoroalkyl substances (PFAS) with maternal post-pregnancy weight trajectory parameters.
Methods: We studied 1106 Project Viva participants with measures of early-pregnancy plasma concentrations of eight PFAS. We measured weight at in-person visits at 6 months and 3, 7, and 12 years after pregnancy and collected self-reported weight via annual questionnaires up to 17 years after pregnancy.
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