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Pathways driving tendinopathy and enthesitis: siblings or distant cousins in musculoskeletal medicine?
Lancet Rheumatol
May 2023
School of Infection and Immunity, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address:
Tendinopathy and enthesitis share clinical, anatomical, and molecular parallels. However, their relationship is complex, presenting challenges in diagnosis and treatment. The biomechanics underlying these pathologies, together with relative immune and stromal contributions to pathology, are characterised by crucial comparative elements.
View Article and Find Full Text PDFIsolating the white matter circuitry of the dorsal language stream: Connectome-Symptom Mapping in stroke induced aphasia.
Hum Brain Mapp
December 2021
Department of Cognitive Science, University of California, Irvine, California, USA.
The application of ℓ1-regularized machine learning models to high-dimensional connectomes offers a promising methodology to assess clinical-anatomical correlations in humans. Here, we integrate the connectome-based lesion-symptom mapping framework with sparse partial least squares regression (sPLS-R) to isolate elements of the connectome associated with speech repetition deficits. By mapping over 2,500 connections of the structural connectome in a cohort of 71 stroke-induced cases of aphasia presenting with varying left-hemisphere lesions and repetition impairment, sPLS-R was trained on 50 subjects to algorithmically identify connectomic features on the basis of their predictive value.
View Article and Find Full Text PDFOpen repair versus EVAR with parallel grafts in patients with juxtarenal abdominal aortic aneurysm excluded from fenestrated endografting.
J Cardiovasc Surg (Torino)
October 2021
Division of Vascular and Endovascular Surgery, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University School of Medicine, Padua, Italy.
Background: We compared the outcomes of open surgical repair (OSR) versus endovascular aortic repair (EVAR) with parallel graft technique (PG) in patients with juxtarenal abdominal aortic aneurysm (JAAA) excluded from fenestrated endovascular aortic repair (FEVAR) due to clinical, anatomical, technical or manufacturing time reasons.
Methods: A single-center analysis of consecutive patients who underwent elective and urgent (within 24-48 hours) repair of JAAA from January 2010 to January 2019 was performed. Two groups were compared: patients excluded from FEVAR and respectively treated by OSR or by PG for JAAA.
The student's dilemma, liver edition: incorporating the sonographer's language into clinical anatomy education.
Anat Sci Educ
February 2016
Department of Emergency Medicine, Yale University, School of Medicine, New Haven, Connecticut.
Anatomy students are often confused by multiple names ascribed to the same structure by different clinical disciplines. Increasingly, sonography is being incorporated into clinical anatomical education, but ultrasound textbooks often use names unfamiliar to the anatomist. Confusion is worsened when ultrasound names ascribed to the same structure actually refer to different structures.
View Article and Find Full Text PDFThe 'Ajuda Paralyses': history of a neuropsychiatric debate in mid-19th-century Portugal.
Brain
October 2010
F. Hoffmann-La Roche, Pharma Research and Exploratory Development, Grenzacherstrasse 124, Basel BS, Switzerland.
The second half of the 19th century witnessed an increasing interest in neurology and psychiatry by Portuguese physicians, in parallel with the overall development of these disciplines in other countries. This process is reflected in the numerous case report publications as well as in debates taking place at the Lisbon Society of Medical Sciences, the major scientific forum of that time. The 'Ajuda Paralyses' were a mysterious succession of epidemics that occurred during 1860-64 in the Ajuda asylum for cholera and yellow fever orphans, which were extensively discussed during 1865-66 by Bernardino Antonio Gomes, Antonio Maria Barbosa, Abel Jordão and Eduardo Motta.
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