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Purpose: Peripheral arterial disease (PAD) is increasingly prevalent, particularly among the aging population. Retrograde tibiopedal access (RTPA) has emerged as a useful endovascular treatment for PAD. However, there is limited research examining factors that influence the efficacy of RTPA.

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Clinical Relevance: Buerger's disease, being a systemic inflammatory vasculopathy, may present with ocular findings.

Background: This study aims to understand the potential role of optical coherence tomography and angiography findings in evaluating the course of Buerger's disease.

Methods: This was a prospective, cross-sectional study that included 25 patients with Buerger's disease (Group 1) and 51 healthy control participants, of whom 27 were smokers (Group 2) and 24 were non-smokers (Group 3).

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Gene Therapy of Thromboangiitis Obliterans with Growth Factor Plasmid (VEGF165) and Autologous Bone Marrow Cells.

Biomedicines

July 2024

Clinical Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.

Article Synopsis
  • A study on gene therapy for critical limb ischemia used VEGF 165 plasmids, with or without stem cells, on 21 patients with thromboangiitis obliterans (TAO).
  • Patients were divided into three groups: dual therapy (cells + plasmid), plasmid only, and a control group receiving saline.
  • Results showed significant improvements in blood flow and pain reduction in the dual therapy group, indicating that this treatment is safe and effective.
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Purpose: Although thrombolysis obliterans (TAO) has been recognized for more than a century, there is no optimal treatment for this disease. The aim of this report was to compare the short-term efficacies of catheter-directed thrombolysis (CDT), percutaneous transluminal angioplasty (PTA) and CDT+PTA in treating TAO disease.

Method: Consecutive patients with TAO treated at Ganzhou People's Hospital between 2012 and 2022 were included in this retrospective study.

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