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A Case of Bronchopneumonia Presenting With Persistent Hiccups Successfully Treated With Clonazepam and a Traditional Kampo Medicine.
Cureus
December 2024
Division of Nephrology, Toho University Sakura Medical Center, Sakura, JPN.
Persistent hiccups are rare but can serve as an early symptom of underlying conditions, including pulmonary infections and cerebrovascular disorders. This case highlights hiccups as a presenting symptom of bronchopneumonia in a hemodialysis patient and explores the effective use of chlorpromazine and Hange-koboku-to (HKT) as symptomatic therapies. Given the potential association of hiccups with neurological conditions, this case underscores the need for comprehensive diagnostic evaluation.
View Article and Find Full Text PDFNuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1.
Adv Sci (Weinh)
December 2024
Department of Systems Biology, Beckman Research Institute, City of Hope, 1500 E Duarte Rd, Duarte, CA, 91010, USA.
Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, a cell signaling-focused CRISPR screen identified cytochrome c oxidase subunit 4 isoform 1 (COX4I1) as a novel vulnerability in acute myeloid leukemia (AML). Depletion of COX4I1 hindered leukemia cell proliferation and impacted in vivo AML progression.
View Article and Find Full Text PDF[Acute cytolytic hepatitis followed by edema associated with the use of antipsychotics neuroleptics: A case report and review of the literature].
Therapie
November 2024
Service de psychiatrie 'A', CHU Hedi Chaker, 3029 Sfax, Tunisie.
CEPHALIC TETANUS: A CASE REPORT AND REVIEW OF LITERATURE.
West Afr J Med
November 2024
Paediatric Infectious Diseases Unit, Department of Paediatrics, Jos University Teaching Hospital/University of Jos, Jos, Plateau State, Nigeria.
Summary/introduction: Cephalic tetanus (CT) constitutes only 1-3% of total reported tetanus cases. It is marked by flaccid paralysis of one or more cranial nerves (CN) with or without spasticity, typically following craniofacial injuries. The facial nerve is the most frequently paralyzed.
View Article and Find Full Text PDFRenal protective potential of pentoxifylline, chlorpromazine, and lovastatin in ischemia-reperfusion injury: An experimental study.
PLoS One
October 2024
Graduate Program in Veterinary Science, Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
Article Synopsis
- The study assessed the protective effects of pentoxifylline, lovastatin, and chlorpromazine against kidney damage caused by ischemia and reperfusion in animals.
- A total of 36 male animals were divided into four groups, with one group receiving no treatment and the others treated with one of the three substances.
- Results showed that while chlorpromazine was effective in the short term, pentoxifylline was the most effective overall in preserving kidney structure, with all three treatments ultimately demonstrating effectiveness.
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