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A Lumbar Drug-Resistant Tuberculosis: A Case Report and Review of Literature.
Infect Drug Resist
December 2024
Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
Introduction: Tuberculosis is prevalent in high-burden countries. However, spinal multi-drug resistant tuberculosis (MDR-TB) in patients with normal immune function is a disease that is prone to misdiagnosis and even delayed diagnosis. Recently, we successfully treated one such patient.
View Article and Find Full Text PDFThe clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models.
Transl Psychiatry
December 2024
School of Psychological Sciences, College of Health and Medicine, University of Tasmania, Tasmania, TAS, Australia.
This study establishes mirdametinib as the first MEK inhibitor that can undergo clinical development for psychiatric indications such as post-traumatic stress disorder (PTSD). PTSD is characterized by persistent traumatic memories with limited effective treatment options. A body of evidence suggests that memory storage is dynamic and constantly updated through post-retrieval modification a process termed reconsolidation.
View Article and Find Full Text PDFSelf-criticism predicts antidepressant effects of intermittent theta-burst stimulation in Major Depressive Disorder.
J Affect Disord
December 2024
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Mathison Centre for Mental Health Research and Education, Calgary, Alberta, Canada. Electronic address:
Article Synopsis
- Self-criticism may increase the effectiveness of rTMS treatment for depression, with higher levels associated with better outcomes when paired with D-Cycloserine, a drug that enhances synaptic plasticity.
- In a trial with 50 adults diagnosed with Major Depressive Disorder, participants received either D-Cycloserine or a placebo alongside daily rTMS sessions targeting the left dorsolateral prefrontal cortex for 4 weeks.
- Results showed a stronger link between self-criticism and treatment improvement when D-Cycloserine was used, indicating that self-criticism could influence the brain circuits involved in depression response to rTMS.
The potential effect of d-cycloserine on the development of anxiety during exposure sessions in patients with agoraphobia.
J Psychiatr Res
October 2024
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences, Campus Charité Mitte, Germany. Electronic address:
Article Synopsis
- The study investigates the impact of d-cycloserine (DCS) on anxiety levels during exposure therapy for patients with agoraphobia compared to a placebo group.
- A total of 73 patients underwent cognitive behavioral therapy with exposure sessions, with the DCS group showing reduced anxiety levels over time while the placebo group exhibited stable anxiety.
- Results indicate that DCS may have short-term benefits in managing anxiety during treatment, but further confirmatory research is necessary to validate these findings.
Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103.
J Med Chem
November 2024
Neuroscience Drug Discovery Denmark, H. Lundbeck A/S, 9 Ottiliavej, Valby, DK-2500 Copenhagen, Denmark.
The discovery of d-cycloserine (), a partial agonist of the NMDA receptor that exhibits antidepressant effects without the psychotomimetic effects of ketamine, has fueled interest in new NMDA-targeting antidepressants. Our objective was to identify potent partial agonists mirroring , particularly tailored for the GluN2B subtype of the NMDA receptor. Through a structure-based drug design approach, we discovered compound .
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