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Personalized Medicine Through Semisolid-Extrusion Based 3D Printing: Dual-Drug Loaded Gummies for Enhanced Patient Compliance.
Pharm Res
January 2025
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
Purpose: The purpose of this research was to develop and characterize dual-drug Isoniazid-Pyridoxine gummies using Semisolid Extrusion (SSE) 3D printing technology, aimed at personalized dosing for a broad patient demographic, from pediatric to geriatric. This study leverages SSE 3D printing, an innovative approach in personalized medicine, to enable precise dose customization and improve patient adherence. By formulating dual drug-loaded gummies, the research addresses the challenges of pill burden and poor palatability associated with traditional tuberculosis regimens, ultimately enhancing the therapeutic experience and effectiveness for patients across various age groups.
View Article and Find Full Text PDFCooperation of Cysteine, Ascorbic Acid, Pyridoxine, and α-Lipoic Acid in Antioxidant Effects on Human Keratinocytes and 3D Human Skin Models.
J Nutr Sci Vitaminol (Tokyo)
January 2025
Narita Development Center, SSP Co., Ltd.
Combinations of cysteine, ascorbic acid, and pyridoxine are frequently used in oral formulations. Although there have been many reports on the efficacy of each of these ingredients, little information is known about their combined effects on skin cells. The purpose of this study was to evaluate the combined effects of cysteine, ascorbic acid, and pyridoxine, as well as the effect of adding α-lipoic acid, on skin cells.
View Article and Find Full Text PDFInvestigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats.
Int J Prev Med
November 2024
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- Malnutrition and low micronutrient levels are common in patients with ulcerative colitis (UC), and this study examined how different vitamin B groups might help improve the condition.
- Experimental colitis was induced in rats, and both high and normal doses of several B vitamins were administered; results showed significant improvements in weight and ulceration measures following treatment.
- While most vitamins showed beneficial anti-inflammatory effects, pyridoxine was less effective in reducing UC symptoms, indicating a need for further research on the clinical implications of these findings.
Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.
Nat Commun
December 2024
ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Department of Systems Biology for Medicine, Fudan University, Shanghai, China.
Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein and nucleic acid biosynthesis, and neurotransmitter production. In humans, thiamine transporters SLC19A2 and SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations in these transporters, which cause thiamine and pyridoxine deficiency, have been implicated in severe neurometabolic diseases.
View Article and Find Full Text PDFPyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments.
Metab Brain Dis
December 2024
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, PR China.
Schizophrenia is a kind of neurodevelopmental mental disorder in which patients begin to experience changes early in their development, typically manifesting around or after puberty and has a fluctuating course. Environmental disturbances during adolescence may be a risk factor for schizophrenia-like deficits. As a better treatment option, preventive intervention prior to schizophrenia may be more beneficial than direct treatment.
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