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Considering the use of GLP-1 receptor agonists in women with obesity prior to pregnancy: a narrative review.
Arch Gynecol Obstet
January 2025
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Grattan St, Parkville, VIC, 3050, Australia.
Purpose: Metabolic disease, including obesity and type 2 diabetes, are amongst the most significant health issues facing women of reproductive age. To date, no antenatal weight management tools have reduced the risk of adverse health outcomes for women with obesity and their offspring, resulting in a shift in focus to the pre-conception period. Although not yet recognised in most international weight management guidelines, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are being increasingly used for weight management prior to conception.
View Article and Find Full Text PDFEvaluating export vulnerability through import demand elasticity in carbon border adjustment contexts: a focus on Türkiye.
Environ Sci Pollut Res Int
January 2025
Department of International Trade and Business, Faculty of Economics and Administrative Sciences, Inonu University, 44000, Malatya, Turkey.
Import demand elasticity (IDE) is a critical metric often employed to guide government decisions regarding tariffs and non-tariff barriers, ensuring that foreign trade remains uninterrupted while optimizing tax revenues. This study, however, leverages IDE to assess the impact of the carbon border adjustment mechanism (CBAM) on Türkiye's decarbonization process. Specifically, the research analyzed the total export quantities and unit prices of four product groups-cement, fertilizers, and inorganic chemicals, steel and iron, and aluminum-exported from Türkiye to the European Union-27 countries under the CBAM framework between 2002 and 2021.
View Article and Find Full Text PDFDNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells.
Cell Mol Life Sci
January 2025
Cam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou, China.
The mechanism by which DNA-damage affects self-renewal and pluripotency remains unclear. DNA damage and repair mechanisms have been largely elucidated in mutated cancer cells or simple eukaryotes, making valid interpretations on early development difficult. Here we show the impact of ionizing irradiation on the maintenance and early differentiation of mouse embryonic stem cells (ESCs).
View Article and Find Full Text PDFSpatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer.
Nat Commun
January 2025
Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.
Pancreatic ductal adenocarcinoma (PDAC) displays a high degree of spatial subtype heterogeneity and co-existence, linked to a diverse microenvironment and worse clinical outcome. However, the underlying mechanisms remain unclear. Here, by combining preclinical models, multi-center clinical, transcriptomic, proteomic, and patient bioimaging data, we identify an interplay between neoplastic intrinsic AP1 transcription factor dichotomy and extrinsic macrophages driving subtype co-existence and an immunosuppressive microenvironment.
View Article and Find Full Text PDFDownregulation of the PI3K/AKT/mTOR/MMP-13 Pathway for Promoting Interface Healing via Lubricating Microspheres.
Acta Biomater
January 2025
Clinical Center for Sports Medicine, Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P. R. China.. Electronic address:
Interface friction impedes tissue healing and stimulates interface cells to produce matrix metalloproteinases (MMPs); however, the precise mechanisms underlying matrix degradation, and the formation of fibrous scars remain unclear. This research involved the development of interface lubricating microspheres that inhibit the PI3K/AKT/mTOR signaling pathway in tenocytes. This inhibition significantly decreased MMP-13 expression and increased COL-1 production, thereby facilitating interface repair and regeneration.
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