AI Article Synopsis
- The study compared the effects of epanolol, diltiazem, and a placebo in 16 patients with chronic stable angina, showing that diltiazem significantly reduced the frequency of angina attacks compared to epanolol.
- Both medications increased treadmill exercise time, but did not improve overall aerobic capacity when compared to a placebo, indicating that patients still had below-normal exercise performance levels.
- The findings suggest that the cardiodepressant effects of the drugs limit oxygen supply to muscles during exercise, leading to symptoms like dyspnoea or fatigue instead of chest pain.
Article Abstract
The effects of epanolol (a new selective beta-adrenoceptor antagonist), diltiazem and placebo were compared in a group of 16 patients with chronic stable angina pectoris. Each patient received each treatment in random order. Diltiazem reduced weekly angina attack rate from 7.2 (95% CI 3.9-10.5) to 3.9 (1.9-5.9) (P less than 0.01), whereas a lesser reduction was observed after epanolol. Both drugs produced a small but significant (P less than 0.05) increase in treadmill exercise time (placebo 474 s (374-574), epanolol 527 s (431-623) and diltiazem 554 s (462-646). However, aerobic work capacity, assessed by peak achieved oxygen consumption, was not different from the placebo value of 21.2 (18.0-24.4) ml.min-1.kg-1, and clearly subnormal when compared to age- and sex-matched controls (33.0 (30.1-35.9) ml.min-1.kg-1). Ventilatory abnormalities and increased lactate levels on active treatment were observed at peak exercise only. We conclude that the cardiodepressant effects of both active drugs limit blood supply to working skeletal muscle, and that chest pain may be replaced by dyspnoea or fatigue as the limiting factors to exercise.
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| http://dx.doi.org/10.1093/oxfordjournals.eurheartj.a060323 | DOI Listing |
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